(Q33636734)

28 July 2017

title

Evolutionary history and functional characterization of the amphibian xenosensor CAR. (English)

1 reference

28 July 2017

Marianne Mathäs

1

1 reference

28 July 2017

Oliver Burk

2

1 reference

28 July 2017

Huan Qiu

3

1 reference

28 July 2017

Christian Nusshag

4

1 reference

28 July 2017

Ute Gödtel-Armbrust

5

1 reference

28 July 2017

Dorothea Baranyai

6

1 reference

28 July 2017

Shiwei Deng

7

1 reference

28 July 2017

Kristin Römer

8

1 reference

28 July 2017

Dieudonné Nem

9

1 reference

28 July 2017

Björn Windshügel

10

1 reference

28 July 2017

Leszek Wojnowski

11

1 reference

28 July 2017

publication date

10 November 2011

1 reference

28 July 2017

published in

Molecular Endocrinology

1 reference

28 July 2017

volume

26

1 reference

28 July 2017

issue

1

1 reference

28 July 2017

page(s)

14-26

1 reference

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

28 July 2017

cites work

1 reference

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Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR

21 June 2018

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21 June 2018

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Ohnologs in the human genome are dosage balanced and frequently associated with disease

21 June 2018

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The cause of global amphibian declines: a developmental endocrinologist's perspective

21 June 2018

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The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability

21 June 2018

1 reference

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Ecological science and tomorrow's world

21 June 2018

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A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.

21 June 2018

1 reference

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Programmed loss of millions of base pairs from a vertebrate genome

21 June 2018

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Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

21 June 2018

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Skin microbes on frogs prevent morbidity and mortality caused by a lethal skin fungus.

21 June 2018

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21 June 2018

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A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

21 June 2018

1 reference

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Intrinsic disorder in nuclear hormone receptors

21 June 2018

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Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species

21 June 2018

1 reference

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Evolution of pharmacologic specificity in the pregnane X receptor

21 June 2018

1 reference

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Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.

21 June 2018

1 reference

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Functional evolution of the vitamin D and pregnane X receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome

21 June 2018

1 reference

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Global patterns of diversification in the history of modern amphibians

21 June 2018

1 reference

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Functional evolution of the pregnane X receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

The UCSC Genome Browser Database: update 2006

21 June 2018

1 reference

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Two rounds of whole genome duplication in the ancestral vertebrate

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

ProtTest: selection of best-fit models of protein evolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer

21 June 2018

1 reference

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Alternatively spliced isoforms of the human constitutive androstane receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

21 June 2018

1 reference

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Human-mouse alignments with BLASTZ

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors

21 June 2018

1 reference

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21 June 2018

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21 June 2018

1 reference

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Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

21 June 2018

1 reference

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DAMBE: software package for data analysis in molecular biology and evolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

MRBAYES: Bayesian inference of phylogenetic trees

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Molecular cloning and functional characterization of a novel nuclear receptor similar to an embryonic benzoate receptor BXR.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Xgrip109: a gamma tubulin-associated protein with an essential role in gamma tubulin ring complex (gammaTuRC) assembly and centrosome function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

A novel nuclear receptor superfamily member in Xenopus that associates with RXR, and shares extensive sequence similarity to the mammalian vitamin D3 receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

The evolution of activity capacity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

The rapid generation of mutation data matrices from protein sequences

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Human colonic adenocarcinoma cells. I. Establishment and description of a new line

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Effects of rifampicin on global gene expression in human small intestine.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Expression pattern of BXR suggests a role for benzoate ligand-mediated signalling in hatching gland function.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417167

Evolution of duplicate genes in a tetraploid animal, Xenopus laevis

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22074953

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1210/ME.2011-1235

1 reference

28 July 2017

1 reference

28 July 2017

1 reference