(Q33661043)

English

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

author name string

Najah Abi-Gerges

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Jean-Pierre Valentin

2

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Chris E Pollard

3

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

language of work or name

0 references

publication date

6 August 2009

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

British Journal of Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

159

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

77-92

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Heterogeneity and cardiac arrhythmias: an overview.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Cell-to-cell electrical interactions during early and late repolarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Prediction of the risk of Torsade de Pointes using the model of isolated canine Purkinje fibres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Nature, significance, and mechanisms of electrical heterogeneities in ventricle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Evidence for gender differences in electrophysiological properties of canine Purkinje fibres.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Drug-induced torsades de pointes and implications for drug development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

The dog's role in the preclinical assessment of QT interval prolongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Species plays an important role in drug-induced prolongation of action potential duration and early afterdepolarizations in isolated Purkinje fibers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Loratadine blockade of K(+) channels in human heart: comparison with terfenadine under physiological conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Current antiarrhythmic drugs: an overview of mechanisms of action and potential clinical utility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Comparison of the cellular electrophysiological characteristics of canine left ventricular epicardium, M cells, endocardium and Purkinje fibres.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Terfenadine blocks time-dependent Ca2+, Na+, and K+ channels in guinea pig ventricular myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Amiodarone-associated proarrhythmic effects. A review with special reference to torsade de pointes tachycardia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Class III Antiarrhythrnic Action Linked with Positive Inotropy: Effects of the d- and 1-Isomer of Sotalol on Isolated Rat Atria at Threshold and Suprathreshold Stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Subsidiary class III effects of beta blockers? A comparison of atenolol, metoprolol, nadolol, oxprenolol and sotalol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

21 June 2018

Points to consider emerging from a mini-workshop on cardiac safety: assessing torsades de pointes liability.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Choice of cardiac tissue in vitro plays an important role in assessing the risk of drug-induced cardiac arrhythmias in human: beyond QT prolongation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Lack of action potential-prolonging effect of terfenadine on rabbit myocardial tissue preparations

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00338.X

21 January 2018

International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability. Notice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

30 October 2018

International Conference on Harmonisation; guidance on S7B Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals; availability. Notice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

30 October 2018

Detection of proarrhythmia in the female rabbit heart: blinded validation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

30 October 2018

Beat-to-beat repolarization variability in ventricular myocytes and its suppression by electrical coupling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

30 October 2018

Attenuation of proarrhythmias related to delayed repolarization by low-dose lidocaine in the anesthetized rabbit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823354

30 October 2018

Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophysiologic effects of the levo- and dextrorotatory isomers of sotalol in isolated cardiac muscle and their in vivo pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electromechanical characterization of the effects of racemic sotalol and its optical isomers on isolated canine ventricular trabecular muscles and Purkinje strands

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative beta-blocking activities and electrophysiologic actions of racemic sotalol and its optical isomers in anesthetized dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular basis of biventricular hypertrophy and arrhythmogenesis in dogs with chronic complete atrioventricular block and acquired torsade de pointes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetrical distribution of ion channels in canine and human left-ventricular wall: epicardium versus midmyocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

QT PRODACT: comparison of non-clinical studies for drug-induced delay in ventricular repolarization and their role in safety evaluation in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences of promethazine and terfenadine on ion channels in guinea pig ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative contributions of TRIaD and QT to proarrhythmia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increasing gap junction coupling reduces transmural dispersion of repolarization and prevents torsade de pointes in rabbit LQT3 model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.2009.00338.X

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

ResearchGate publication ID

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