(Q33685619)

28 July 2017

title

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis (English)

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28 July 2017

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15

Pier Paolo Pandolfi

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Arkaitz Carracedo

5

object named as

Arkaitz Carracedo

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28 July 2017

2

Caterina Nardella

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28 July 2017

8

Shohreh Varmeh

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28 July 2017

1

Andrea Alimonti

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28 July 2017

4

John G Clohessy

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28 July 2017

3

Zhenbang Chen

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28 July 2017

14

Howard I Scher

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28 July 2017

Lloyd C Trotman

6

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28 July 2017

Ke Cheng

7

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28 July 2017

Sara C Kozma

9

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28 July 2017

George Thomas

10

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28 July 2017

Erika Rosivatz

11

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28 July 2017

Rudiger Woscholski

12

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28 July 2017

Francesco Cognetti

13

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28 July 2017

language of work or name

English

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publication date

8 February 2010

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Journal of Clinical Investigation

28 July 2017

published in

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28 July 2017

volume

120

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28 July 2017

issue

3

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28 July 2017

page(s)

681-693

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describes a project that uses

28 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2827955/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Differential p53-independent outcomes of p19(Arf) loss in oncogenesis

1 reference

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Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

14 July 2018

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Breaking news: high-speed race ends in arrest--how oncogenes induce senescence.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

14 July 2018

Cancer statistics, 2007

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

mTOR and cancer: insights into a complex relationship

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

RETRACTED: Small molecule-based reversible reprogramming of cellular lifespan

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Identification of a tumour suppressor network opposing nuclear Akt function

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

mTOR and cancer: reason for dancing at the crossroads?

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

BRAFE600-associated senescence-like cell cycle arrest of human naevi

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Tumour biology: senescence in premalignant tumours

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Tumour stem cells and drug resistance

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Pten dose dictates cancer progression in the prostate

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

A PCR primer bank for quantitative gene expression analysis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Tumor cell senescence in cancer treatment

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Pten is essential for embryonic development and tumour suppression

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

p53 is mutated in a subset of advanced-stage prostate cancers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Suppressing cancer: the importance of being senescent.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Oncogene-induced senescence as an initial barrier in lymphoma development

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

p19ARF links the tumour suppressor p53 to Ras

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827955

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20197621

12 December 2020

inferred from PubMed ID database lookup

Isolation of Polysomal RNA for Microarray Analysis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20197621

12 December 2020

inferred from PubMed ID database lookup

Clinical significance of p53 alterations in surgically treated prostate cancers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20197621

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1172/JCI40535

1 reference

28 July 2017

1 reference

28 July 2017

1 reference