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English
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.
scientific article published on January 2007
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
title
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
main subject
DNA damage
0 references
author
Frédérick A Mallette
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
Gerardo Ferbeyre
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
author name string
Marie-France Gaumont-Leclerc
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
publication date
1 January 2007
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
published in
Genes & Development
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
volume
21
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
issue
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
page(s)
43-48
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
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DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation
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PubMed Central
reference URL
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29 May 2018
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
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PubMed Central
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29 May 2018
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
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PubMed Central
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29 May 2018
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
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29 May 2018
Intrinsic tumour suppression
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29 May 2018
PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence
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29 May 2018
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo
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29 May 2018
A DNA damage checkpoint response in telomere-initiated senescence
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29 May 2018
High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts
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PubMed Central
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29 May 2018
Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo
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29 May 2018
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
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29 May 2018
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
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PubMed Central
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29 May 2018
Checking on the fork: the DNA-replication stress-response pathway
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29 May 2018
53BP1, a mediator of the DNA damage checkpoint
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29 May 2018
Interfaces between the detection, signaling, and repair of DNA damage
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29 May 2018
Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition
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29 May 2018
Chk2 activation and phosphorylation-dependent oligomerization
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29 May 2018
Oncogenic ras and p53 cooperate to induce cellular senescence
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PubMed Central
reference URL
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29 May 2018
p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo
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29 May 2018
Role of p14(ARF) in replicative and induced senescence of human fibroblasts
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29 May 2018
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
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29 May 2018
Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
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29 May 2018
Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
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PubMed Central
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29 May 2018
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
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PubMed Central
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29 May 2018
PML is induced by oncogenic ras and promotes premature senescence
1 reference
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PubMed Central
reference URL
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29 May 2018
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
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29 May 2018
STATs in oncogenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
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29 May 2018
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
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29 May 2018
Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
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29 May 2018
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
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29 May 2018
E1A signaling to p53 involves the p19(ARF) tumor suppressor
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
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29 May 2018
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
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29 May 2018
Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
retrieved
29 May 2018
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
retrieved
29 May 2018
RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
retrieved
17 August 2018
Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
retrieved
17 August 2018
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
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17 August 2018
Escape from premature senescence is not sufficient for oncogenic transformation by Ras.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
retrieved
17 August 2018
p19ARF links the tumour suppressor p53 to Ras
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898
retrieved
1 December 2018
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/17210786
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/17210786
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/17210786
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1101/GAD.1487307
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
PMC publication ID
1759898
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
PubMed publication ID
17210786
1 reference
stated in
Europe PubMed Central
PMC publication ID
1759898
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 December 2019
ResearchGate publication ID
6590150
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