(Q33702000)

28 July 2017

title

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules (English)

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28 July 2017

David R Spring

3

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author name string

Warren R J D Galloway

series ordinal

1

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28 July 2017

Albert Isidro-Llobet

series ordinal

2

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28 July 2017

language of work or name

English

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publication date

21 September 2010

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28 July 2017

published in

Nature Communications

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28 July 2017

volume

1

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28 July 2017

issue

1

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page(s)

80

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Molecular shape diversity of combinatorial libraries: a prerequisite for broad bioactivity.

28 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1081

Privileged structures: applications in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1081

Molecular characterisation of the dominant UK methicillin-resistant Staphylococcus aureus strains, EMRSA-15 and EMRSA-16.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1081

Target-oriented and diversity-oriented organic synthesis in drug discovery

21 January 2018

1 reference

12 December 2020

Reagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical space

1 reference

12 December 2020

Gemmacin B: bringing diversity back into focus

1 reference

12 December 2020

1 reference

12 December 2020

Fragment-based ligand discovery

1 reference

12 December 2020

Aziridines as intermediates in diversity-oriented syntheses of alkaloids

1 reference

12 December 2020

Small molecule shape-fingerprints

1 reference

12 December 2020

Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesisElectronic supplementary information (ESI) available: experimental techniques, appara

1 reference

12 December 2020

Chemical genetics to chemical genomics: small molecules offer big insights

1 reference

12 December 2020

Synthesis of Diverse Lactam Carboxamides Leading to the Discovery of a New Transcription-Factor Inhibitor

1 reference

12 December 2020

Synthesis of unprecedented scaffold diversity

1 reference

12 December 2020

Assessment of structural diversity in combinatorial synthesis

1 reference

12 December 2020

Interactive exploration of chemical space with Scaffold Hunter

1 reference

12 December 2020

Structural diversity of organic chemistry. A scaffold analysis of the CAS Registry.

1 reference

12 December 2020

Can we rationally design promiscuous drugs?

1 reference

12 December 2020

Diversity oriented synthesis: a challenge for synthetic chemists.

1 reference

12 December 2020

Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates

1 reference

12 December 2020

Scaffold composition and biological relevance of screening libraries.

1 reference

12 December 2020

Escape from flatland: increasing saturation as an approach to improving clinical success

1 reference

12 December 2020

Skeletal diversity construction via a branching synthetic strategy

1 reference

12 December 2020

A Synthesis Strategy Yielding Skeletally Diverse Small Molecules Combinatorially

1 reference

12 December 2020

Navigating chemical space for biology and medicine

1 reference

12 December 2020

Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform

1 reference

12 December 2020

Multistep microwave-assisted divergent synthesis of indolo-fused pyrazino-/diazepinoquinoxalinones on PEG support

1 reference

12 December 2020

Drugs for bad bugs: confronting the challenges of antibacterial discovery

1 reference

12 December 2020

Teaching target-oriented and diversity-oriented organic synthesis at Harvard University

1 reference

12 December 2020

Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach

1 reference

12 December 2020

Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis

1 reference

12 December 2020

Managing molecular diversity

1 reference

12 December 2020

Diversity-oriented synthesis; a spectrum of approaches and results

1 reference

12 December 2020

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

1 reference

12 December 2020

Diversity-oriented synthesis; a challenge for synthetic chemistsElectronic supplementary information (ESI) available: Excel file of all the FDA new molecular entities between the years 1998 and July 2003, and new drug approvals between the years 1990

1 reference

12 December 2020

Chemical genetics: elucidating biological systems with small-molecule compounds

1 reference

12 December 2020

Dominance of EMRSA-15 and -16 among MRSA causing nosocomial bacteraemia in the UK: analysis of isolates from the European Antimicrobial Resistance Surveillance System (EARSS).

1 reference

12 December 2020

A small molecule that binds Hedgehog and blocks its signaling in human cells

1 reference

12 December 2020

Diversity-oriented synthetic approach to naturally abundant S-amino acid based benzannulated enantiomerically pure medium ring heterocyclic scaffolds employing inter- and intramolecular mitsunobu reactions

1 reference

12 December 2020

Breaking the spell: drug discovery based on modulating protein-protein interactions

1 reference

12 December 2020

Integration of fragment screening and library design

1 reference

12 December 2020

Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?

1 reference

12 December 2020

Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions

1 reference

12 December 2020

"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins

1 reference

12 December 2020

Charting biologically relevant chemical space: a structural classification of natural products (SCONP)

1 reference

12 December 2020

Recent advances in multicomponent reactions for diversity-oriented synthesis

1 reference

12 December 2020

Stereochemical and skeletal diversity arising from amino propargylic alcohols

1 reference

12 December 2020

Application of combinatorial chemistry science on modern drug discovery

1 reference

12 December 2020

Diversity-oriented synthesis of bicyclic and tricyclic alkaloids

1 reference

12 December 2020

Anti-MRSA agent discovery using diversity-oriented synthesis

1 reference

12 December 2020

Generating Diverse Skeletons of Small Molecules Combinatorially

1 reference

12 December 2020

What is principal component analysis?

1 reference

12 December 2020

Current strategies for diversity-oriented synthesis

1 reference

12 December 2020

1 reference

12 December 2020

On the potential of natural products in the discovery of pharma leads: a case for reassessment

1 reference

12 December 2020

Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays.

1 reference

12 December 2020

Natural products as sources of new drugs over the last 25 years

1 reference

12 December 2020

Diversity-oriented synthesis: exploring the intersections between chemistry and biology

1 reference

12 December 2020

Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons

1 reference

12 December 2020

Biology-inspired synthesis of compound libraries

1 reference

12 December 2020

A decade of fragment-based drug design: strategic advances and lessons learned

1 reference

12 December 2020

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis

1 reference

12 December 2020

1 reference

12 December 2020

Molecular diversity through sugar scaffolds

1 reference

12 December 2020

An Oligomer-Based Approach to Skeletal Diversity in Small-Molecule Synthesis

1 reference

12 December 2020

The principle of complementarity: chemical versus biological space

1 reference

12 December 2020

Antibacterial natural products in medicinal chemistry--exodus or revival?

1 reference

12 December 2020

Bioactivity-guided mapping and navigation of chemical space.

1 reference

12 December 2020

The discovery of antibacterial agents using diversity-oriented synthesis

1 reference

12 December 2020

The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis

1 reference

12 December 2020

Enriching chemical space with diversity-oriented synthesis

1 reference

12 December 2020

A planning strategy for diversity-oriented synthesis

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1081

7 January 2021

Molecular diversity by design

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1081

7 January 2021

Towards the optimal screening collection: a synthesis strategy

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1081

7 January 2021

Synthesis of natural-product-like molecules with over eighty distinct scaffolds

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1081

7 January 2021

Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1081

7 January 2021

Thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis (FAP): Memorial Sloan-Kettering Cancer Center (MSKCC) registry experience

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1081

7 January 2021

Dormancy and persistence in chronic infection: role of the general stress response in resistance to chemotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1081

7 January 2021

Identifiers

DOI

10.1038/NCOMMS1081

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Dimensions Publication ID

28 July 2017

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1031283139

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1 reference