(Q28298611)

Hit and lead generation: beyond high-throughput screening

21 April 2017

1 reference

Modern biomedical research: an internally self-consistent universe with little contact with medical reality?

21 April 2017

1 reference

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

21 April 2017

1 reference

Site-directed ligand discovery

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

21 April 2017

1 reference

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

Discovering high-affinity ligands for proteins: SAR by NMR

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

Chemical genetics resulting from a passion for synthetic organic chemistry

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

NIH Molecular Libraries Initiative

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Comprehensive Survey of Combinatorial Library Synthesis: 2002

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Selective optimization of side activities: another way for drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Knockouts model the 100 best-selling drugs--will they model the next 100?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Chemical genetics: exploring and controlling cellular processes with chemical probes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Kinase inhibitors: not just for kinases anymore

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Comparison of Assay Technologies for a Nuclear Receptor Assay Screen Reveals Differences in the Sets of Identified Functional Antagonists

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Prediction of biological activity for high-throughput screening using binary kernel discrimination.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Nonleadlikeness and leadlikeness in biochemical screening

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Biochemical mechanisms of drug action: what does it take for success?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Drug-like annotation and duplicate analysis of a 23-supplier chemical database totalling 2.7 million compounds

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Functional group contributions to drug-receptor interactions.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Molecular complexity and its impact on the probability of finding leads for drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

From magic bullets to designed multiple ligands

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

The Nobel chronicles. 1988: James Whyte Black, (b 1924), Gertrude Elion (1918-99), and George H Hitchings (1905-98).

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Implications of protein flexibility for drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Antibody libraries in drug and target discovery.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Designing proteins that work using recombinant technologies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Novel chemical genetic approaches to the discovery of signal transduction inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Unlocking the potential of the human genome with RNA interference

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Intracellular antibodies as specific reagents for functional ablation: future therapeutic molecules

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Fragment-based lead discovery

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

SAR by MS: a ligand based technique for drug lead discovery against structured RNA targets

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Discovering novel ligands for macromolecules using X-ray crystallographic screening

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

SAR and X-ray. A new approach combining fragment-based screening and rational drug design: application to the discovery of nanomolar inhibitors of Src SH2.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

High-throughput crystallography for lead discovery in drug design.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

The growing impact of click chemistry on drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Tethering: fragment-based drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Chemography: the art of navigating in chemical space.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Chemical space navigation in lead discovery

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Characteristic physical properties and structural fragments of marketed oral drugs.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Can we learn to distinguish between "drug-like" and "nondrug-like" molecules?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Toward designing drug-like libraries: a novel computational approach for prediction of drug feasibility of compounds

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Recognizing molecules with drug-like properties

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Drug-like properties and the causes of poor solubility and poor permeability

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Simple selection criteria for drug-like chemical matter

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Molecular properties that influence the oral bioavailability of drug candidates

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Drugs, leads, and drug-likeness: an analysis of some recently launched drugs

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Prediction of 'drug-likeness'.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Selection criteria for drug-like compounds

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Allosteric inhibition through core disruption

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03193

7 January 2021

Identifiers

DOI

10.1038/NATURE03193

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

ADS bibcode

2004Natur.432..855L

0 references

1025290270

0 references

Fatcat ID

release_4x7ohql36jaa3em35x6kzh7nwa

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4x7ohql36jaa3em35x6kzh7nwa

24 November 2022

mapped directly with Wikidata item

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

15602551

1 reference

Consolidated OpenCitations Corpus – April 2017