(Q33714946)

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Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors

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Europe PubMed Central

PubMed publication ID

28 July 2017

Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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Quanwen Li

1

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Europe PubMed Central

PubMed publication ID

28 July 2017

Albert B Chow

2

1 reference

Europe PubMed Central

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28 July 2017

Raymond R Mattingly

3

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Europe PubMed Central

PubMed publication ID

28 July 2017

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publication date

1 December 2009

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Europe PubMed Central

PubMed publication ID

28 July 2017

Journal of Pharmacology and Experimental Therapeutics

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Europe PubMed Central

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28 July 2017

332

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Europe PubMed Central

PubMed publication ID

28 July 2017

3

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Europe PubMed Central

PubMed publication ID

28 July 2017

821-828

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

1 reference

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Triple-negative breast cancer: risk factors to potential targets

1 reference

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Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells

1 reference

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p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer

1 reference

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

1 reference

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Oncogene addiction: setting the stage for molecularly targeted cancer therapy

1 reference

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Experimental anti-tumor therapy in 3-D: spheroids--old hat or new challenge?

1 reference

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The selectivity of protein kinase inhibitors: a further update

1 reference

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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

1 reference

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Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

1 reference

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28 July 2018

Nitric oxide attenuates resistance to doxorubicin in three-dimensional aggregates of human breast carcinoma cells

1 reference

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The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines

1 reference

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A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel.

1 reference

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28 July 2018

Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

1 reference

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28 July 2018

Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis

1 reference

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28 July 2018

CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)

1 reference

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28 July 2018

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

1 reference

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28 July 2018

Modeling tissue-specific signaling and organ function in three dimensions

1 reference

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28 July 2018

Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts

1 reference

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28 July 2018

Multicellular resistance: a paradigm for clinical resistance?

1 reference

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28 July 2018

Adhesion-dependent multicellular drug resistance.

1 reference

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28 July 2018

Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology

1 reference

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28 July 2018

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

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28 July 2018

Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells

1 reference

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28 July 2018

In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.

1 reference

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30 October 2018

Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients

1 reference

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30 October 2018

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab.

1 reference

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30 October 2018

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

1 reference

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30 October 2018

Down-regulation of growth factor-stimulated MAP kinase signaling in cytotoxic drug-resistant human neuroblastoma cells

1 reference

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30 October 2018

Ras activation in human breast cancer

1 reference

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30 October 2018

Identifiers

10.1124/JPET.109.160390

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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