(Q33715301)

28 July 2017

title

Assay development and high-throughput screening of small molecular c-Abl kinase activators (English)

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28 July 2017

Josh Cottom

1

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28 July 2017

Glenn Hofmann

2

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28 July 2017

Brett Siegfried

3

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28 July 2017

Jingsong Yang

4

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28 July 2017

Hong Zhang

5

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28 July 2017

Tracey Yi

6

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28 July 2017

Thau F Ho

7

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28 July 2017

Chad Quinn

8

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28 July 2017

Da-Yuan Wang

9

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28 July 2017

Kyung Johanson

10

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28 July 2017

Robert S Ames

11

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28 July 2017

Hu Li

12

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28 July 2017

publication date

11 October 2010

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Journal of Biomolecular Screening

28 July 2017

published in

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28 July 2017

volume

16

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28 July 2017

issue

1

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28 July 2017

page(s)

53-64

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Targeting the AMPK pathway for the treatment of Type 2 diabetes

28 July 2017

cites work

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https://api.crossref.org/works/10.1177%2F1087057110384133

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110384133

Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110384133

AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110384133

Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesis

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110384133

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Abl tyrosine kinase in signal transduction and cell-cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110384133

Cycling, stressed-out and nervous: cellular functions of c-Abl

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110384133

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110384133

Structural basis for the autoinhibition of c-Abl tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

A myristoyl/phosphotyrosine switch regulates c-Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Chronic myeloid leukaemia

21 January 2018

1 reference

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Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110384133

A phase II trial of imatinib mesylate monotherapy in patients with metastatic breast cancer.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110384133

The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110384133

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Apparent activity in high-throughput screening: origins of compound-dependent assay interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Evaluation of compound interference in immobilized metal ion affinity-based fluorescence polarization detection with a four million member compound collection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Allosteric inhibitors of Bcr-abl-dependent cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

Promiscuous aggregate-based inhibitors promote enzyme unfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110384133

21 January 2018

Identifiers

DOI

10.1177/1087057110384133

1 reference

28 July 2017

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