(Q33717728)

English

Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959476%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959476%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

protein evolution

0 references

protein folding

0 references

1 reference

based on heuristic

inferred from title

Charles T. Roberts

9

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959476%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author name string

Youhei Sohma

1

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13 February 2020

Qing-xin Hua

2

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13 February 2020

Ming Liu

3

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13 February 2020

Nelson B Phillips

4

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13 February 2020

Shi-Quan Hu

5

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13 February 2020

Jonathan Whittaker

6

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13 February 2020

Linda J Whittaker

7

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13 February 2020

Aubree Ng

8

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13 February 2020

Peter Arvan

10

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13 February 2020

Stephen B H Kent

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959476%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Michael A Weiss

12

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13 February 2020

language of work or name

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publication date

3 December 2009

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13 February 2020

Journal of Biological Chemistry

1 reference

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13 February 2020

285

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13 February 2020

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959476%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

5040-5055

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959476%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Crystal Structure of a"Nonfoldable"Insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Proinsulin and the genetics of diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Proinsulin maturation, misfolding, and proteotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Insulin gene mutations as a cause of permanent neonatal diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

TROSY of side-chain amides in large proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Characterization of the functional insulin binding epitopes of the full-length insulin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

A peptide model of insulin folding intermediate with one disulfide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Emerging roles for orphan G-protein-coupled receptors in the cardiovascular system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Endoplasmic reticulum stress and the development of diabetes: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Structural biology of insulin and IGF1 receptors: implications for drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Structural origins of the functional divergence of human insulin-like growth factor-I and insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Activation of orphan receptors by the hormone relaxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

A cavity-forming mutation in insulin induces segmental unfolding of a surrounding α-helix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Application of circular dichroism to study RNA folding transitions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Protein misfolding, evolution and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Identification of INSL5, a new member of the insulin superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

The insulin-like growth factor (IGF)binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Protein folding coupled to disulphide bond formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

ASPB10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: evidence for enhanced interactions with the insulin-like growth factor-I receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Solution structure of a mini IGF-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Solution structure of an engineered insulin monomer at neutral pH

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

The roles of partly folded intermediates in protein folding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Three-dimensional structure of human insulin-like growth factor-I (IGF-I) determined by 1H-NMR and distance geometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

A human cDNA coding for the Leydig insulin-like peptide (Ley I-L)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Structure of a protein in a kinetic trap

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

How does a protein fold?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Three-dimensional solution structure of bombyxin-II an insulin-like peptide of the silkmoth Bombyx mori: structural comparison with insulin and relaxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Insulin-like growth factor II precursor gene organization in relation to insulin gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Structure of a genomic clone encoding biologically active human relaxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Synthesis of Insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Insulin biosynthesis: evidence for a precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Principles that govern the folding of protein chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

A superactive insulin: [B10-aspartic acid]insulin(human).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

The structure of 2Zn pig insulin crystals at 1.5 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Structure and activity dependence of recombinant human insulin-like growth factor II on disulfide bond pairing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Receptor binding redefined by a structural switch in a mutant human insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Manipulation of the biosynthesis of protein-modifying glycoconjugates by the use of specific inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Kinetic role of nonnative species in the folding of bovine pancreatic trypsin inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

What the papers say: Protein folding pathways determined using disulphide bonds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836107

21 June 2018

Oxidative refolding of insulin-like growth factor 1 yields two products of similar thermodynamic stability: a bifurcating protein-folding pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Three-dimensional solution structure of a disulfide bond isomer of the human insulin-like growth factor-I.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

The different folding behavior of insulin and insulin-like growth factor 1 is mainly controlled by their B-chain/domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

The different energetic state of the intra A-chain/domain disulfide of insulin and insulin-like growth factor 1 is mainly controlled by their B-chain/domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Sequences of B-chain/domain 1-10/1-9 of insulin and insulin-like growth factor 1 determine their different folding behavior.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Synthesis of the antibacterial peptide cecropin A (1-33).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Comparative properties of insulin-like growth factor 1 (IGF-1) and [Gly7D-Ala]IGF-1 prepared by total chemical synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-thioester building blocks.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Role of native disulfide bonds in the structure and activity of insulin-like growth factor 1: genetic models of protein-folding intermediates.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Sequence differences between glycosylated and non-glycosylated Asn-X-Thr/Ser acceptor sites: implications for protein engineering

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Drosophila ALS regulates growth and metabolism through functional interaction with insulin-like peptides.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Monomeric insulins obtained by protein engineering and their medical implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.062992

21 January 2018

Insulin-like growth factors I and II are unable to form and maintain their native disulfides under in vivo redox conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative reduction/oxidation studies with single chain des-(B30) insulin and porcine proinsulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disulfide exchange folding of insulin-like growth factor I

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hierarchical protein folding: asymmetric unfolding of an insulin analogue lacking the A7-B7 interchain disulfide bridge

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steric requirements at position B12 for high biological activity in insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I and its binding proteins: a study of the binding interface using B-domain analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1H-NMR Assignment and Secondary Structure of Human Insulin-Like Growth Factor-I(IGF-I) in Solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The folding nucleus of the insulin superfamily: a flexible peptide model foreshadows the native state

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An overview of insulin evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineering stability of the insulin monomer fold with application to structure-activity relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of an equilibrium intermediate in the folding of a monomeric insulin analog

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implications of invariant residue LeuB6 in insulin-receptor interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of an optimized refolding process for recombinant Ala-Glu-IGF-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights into the mechanism and catalysis of the native chemical ligation reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hierarchical protein "un-design": insulin's intrachain disulfide bridge tethers a recognition alpha-helix

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Native and non-native structure in a protein-folding intermediate: spectroscopic studies of partially reduced IGF-I and an engineered alanine model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic role of a meta-stable native-like two-disulphide species in the folding transition of bovine pancreatic trypsin inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and Biological Activity of Two Disulphide Bond Isomers of Human Insulin: [A7-A11 ,A6-B7-Cystine]- and [A6-A7,A11-B7-Cystine]insulin (Human)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing the disulfide folding pathway of insulin-like growth factor-I

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sequence determinant causing different folding behaviors of insulin and insulin-like growth factor-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disulphide-coupled protein folding pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogenic activity and receptor reactivity of hybrid molecules containing portions of the insulin-like growth factor I (IGF-I), IGF-II, and insulin molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folding of insulin-like growth factor I is thermodynamically controlled by insulin-like growth factor binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1.42A crystal structure of mini-IGF-1(2): an analysis of the disulfide isomerization property and receptor binding property of IGF-1 based on the three-dimensional structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein folding

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disulfide exchange folding of disulfide mutants of insulin-like growth factor I in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ neutralization in Boc-chemistry solid phase peptide synthesis. Rapid, high yield assembly of difficult sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/19959476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.062992

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959476%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959476%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959476%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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