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Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway.
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Europe PubMed Central
PMC publication ID
1069617
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798180%20AND%20SRC:MED&resulttype=core&format=json
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10 January 2020
title
Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway
(English)
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Europe PubMed Central
PMC publication ID
1069617
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798180%20AND%20SRC:MED&resulttype=core&format=json
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10 January 2020
main subject
Numb Dmel_CG3779
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GOA release 2020-03-11
author
Santiago B Rompani
series ordinal
2
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Europe PubMed Central
PMC publication ID
1069617
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798180%20AND%20SRC:MED&resulttype=core&format=json
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10 January 2020
Yan Zhou
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4
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Europe PubMed Central
PMC publication ID
1069617
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798180%20AND%20SRC:MED&resulttype=core&format=json
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10 January 2020
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Haiyan Tang
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1
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1069617
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10 January 2020
Joshua B Atkins
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3
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1069617
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10 January 2020
Thomas Osterwalder
series ordinal
5
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PMC publication ID
1069617
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10 January 2020
Weimin Zhong
series ordinal
6
1 reference
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Europe PubMed Central
PMC publication ID
1069617
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10 January 2020
language of work or name
English
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publication date
1 April 2005
1 reference
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Europe PubMed Central
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1069617
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10 January 2020
published in
Molecular and Cellular Biology
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PMC publication ID
1069617
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10 January 2020
volume
25
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PMC publication ID
1069617
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798180%20AND%20SRC:MED&resulttype=core&format=json
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10 January 2020
issue
8
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Europe PubMed Central
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1069617
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retrieved
10 January 2020
page(s)
2899-2909
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Europe PubMed Central
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1069617
reference URL
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10 January 2020
cites work
Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization
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PubMed Central
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Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth.
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21 June 2018
The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling
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PubMed Central
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21 June 2018
Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis
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PubMed Central
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21 June 2018
EH and UIM: endocytosis and more
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21 June 2018
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
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21 June 2018
Diversifying neural cells through order of birth and asymmetry of division
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21 June 2018
Progenitor cell maintenance requires numb and numblike during mouse neurogenesis
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21 June 2018
Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts
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PubMed Central
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21 June 2018
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
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PubMed Central
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21 June 2018
When cell biology meets development: endocytic regulation of signaling pathways
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21 June 2018
The Lnx family proteins function as molecular scaffolds for Numb family proteins
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
Siah-1 binds and regulates the function of Numb
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
Numb is an endocytic protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
Mouse numb is an essential gene involved in cortical neurogenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
The EH network
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
Dominant-negative mutation in the beta2 and beta6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.
1 reference
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PubMed Central
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21 June 2018
Notch signaling: cell fate control and signal integration in development
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PubMed Central
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21 June 2018
The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15.
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PubMed Central
reference URL
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21 June 2018
Dap160, a neural-specific Eps15 homology and multiple SH3 domain-containing protein that interacts with Drosophila dynamin
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
The Mdm2 oncoprotein interacts with the cell fate regulator Numb
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX
1 reference
stated in
PubMed Central
reference URL
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21 June 2018
Requirement for dynamin during Notch signaling in Drosophila neurogenesis.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
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21 June 2018
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Control of daughter cell fates during asymmetric division: interaction of Numb and Notch
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Numb antagonizes Notch signaling to specify sibling neuron cell fates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Hairless is required for the development of adult sensory organ precursor cells in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
21 June 2018
Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
30 October 2018
Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
30 October 2018
Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
30 October 2018
Unequal segregation of Neuralized biases Notch activation during asymmetric cell division
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
30 October 2018
A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
30 October 2018
Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
30 October 2018
Heritable gene silencing in Drosophila using double-stranded RNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
30 October 2018
A genome-wide search for synaptic vesicle cycle proteins in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
30 October 2018
Role of Drosophila alpha-adaptin in presynaptic vesicle recycling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069617
retrieved
30 October 2018
Functional analysis of the Numb phosphotyrosine-binding domain using site-directed mutagenesis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15798180
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.25.8.2899-2909.2005
1 reference
stated in
Europe PubMed Central
PMC publication ID
1069617
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
PMC publication ID
1069617
1 reference
stated in
Europe PubMed Central
PMC publication ID
1069617
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
PubMed publication ID
15798180
1 reference
stated in
Europe PubMed Central
PMC publication ID
1069617
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
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