(Q33726840)

28 July 2017

title

Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization (English)

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28 July 2017

Hongyuan Mao

1

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28 July 2017

James J Graziano

2

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28 July 2017

Tyson M A Chase

3

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28 July 2017

Cornelia A Bentley

4

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28 July 2017

Omar A Bazirgan

5

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28 July 2017

Neil P Reddy

6

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28 July 2017

Byeong Doo Song

7

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28 July 2017

Vaughn V Smider

8

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28 July 2017

publication date

24 October 2010

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28 July 2017

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28 July 2017

volume

28

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28 July 2017

issue

11

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28 July 2017

page(s)

1195-1202

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Continuous cultures of fused cells secreting antibody of predefined specificity

28 July 2017

cites work

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21 January 2018

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A microengraving method for rapid selection of single cells producing antigen-specific antibodies

21 January 2018

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Selecting and screening recombinant antibody libraries

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Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda

21 January 2018

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Phage antibodies: filamentous phage displaying antibody variable domains

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Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries.

21 January 2018

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Yeast surface display for screening combinatorial polypeptide libraries

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Isolation of human monoclonal antibodies by mammalian cell display

21 January 2018

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Isolation of anti-CD22 Fv with high affinity by Fv display on human cells

21 January 2018

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Stochastic modeling and optimization of phage display

21 January 2018

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Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.

21 January 2018

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Light-directed, spatially addressable parallel chemical synthesis

21 January 2018

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Microarrays of cells expressing defined cDNAs

21 January 2018

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The protecton: the unit of humoral immunity selected by evolution

21 January 2018

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Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities

21 January 2018

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Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibility

21 January 2018

1 reference

The immunological evolution of catalysis

21 January 2018

1 reference

Exploring the energy landscape of antibody-antigen complexes: protein dynamics, flexibility, and molecular recognition

21 January 2018

1 reference

Structural plasticity and the evolution of antibody affinity and specificity

21 January 2018

1 reference

Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics

21 January 2018

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Germline antibody recognition of distinct carbohydrate epitopes

21 January 2018

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Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus

21 January 2018

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The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus

21 January 2018

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The end-joining reaction in V(D)J recombination

21 January 2018

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Mice lacking terminal deoxynucleotidyl transferase: adult mice with a fetal antigen receptor repertoire

21 January 2018

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By-passing selection: direct screening for antibody-antigen interactions using protein arrays

21 January 2018

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Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination

21 January 2018

1 reference

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells

21 January 2018

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Directed evolution and identification of control regions of ColE1 plasmid replication origins using only nucleotide deletions

21 January 2018

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Co-expression of antibody fab heavy and light chain genes from separate evolved compatible replicons in E. coli

21 January 2018

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Molecular cloning of delta-4, a new mouse and human Notch ligand

21 January 2018

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Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

21 January 2018

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Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

21 January 2018

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Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer

21 January 2018

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DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

21 January 2018

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Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function

21 January 2018

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Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth

21 January 2018

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Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines

21 January 2018

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Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation

21 January 2018

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Selection and application of human single chain Fv antibody fragments from a semi-synthetic phage antibody display library with designed CDR3 regions

21 January 2018

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Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewisx and Lewisx

21 January 2018

1 reference

By-passing immunization: building high affinity human antibodies by chain shuffling

21 January 2018

1 reference

Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigens

21 January 2018

1 reference

Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library

21 January 2018

1 reference

The impact of structural genomics: expectations and outcomes

21 January 2018

1 reference

High-throughput crystallography for structural genomics

21 January 2018

1 reference

Exploration of specificity in germline monoclonal antibody recognition of a range of natural and synthetic epitopes

21 January 2018

1 reference

In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity

21 January 2018

1 reference

Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines

21 January 2018

1 reference

Stepwise in vitro affinity maturation of Vitaxin, an alphav beta3-specific humanized mAb.

21 January 2018

1 reference

Isolation and characterization of an anti-CD16 single-chain Fv fragment and construction of an anti-HER2/neu/anti-CD16 bispecific scFv that triggers CD16-dependent tumor cytolysis

21 January 2018

1 reference

Engineering novel binding proteins from nonimmunoglobulin domains

21 January 2018

1 reference

Alternative non-antibody scaffolds for molecular recognition

21 January 2018

1 reference

A potent erythropoietin-mimicking human antibody interacts through a novel binding site

21 January 2018

1 reference

Characterization of a novel anti-DR5 monoclonal antibody WD1 with the potential to induce tumor cell apoptosis.

21 January 2018

1 reference

Selection of phage antibodies by binding affinity

21 January 2018

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Chronic DLL4 blockade induces vascular neoplasms

21 January 2018

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A monoclonal autoantibody that promotes central nervous system remyelination in a model of multiple sclerosis is a natural autoantibody encoded by germline immunoglobulin genes

21 January 2018

1 reference

12 December 2020

Selection of phage antibodies by binding affinity. Mimicking affinity maturation

1 reference

12 December 2020

Dll4, a novel Notch ligand expressed in arterial endothelium

1 reference

12 December 2020

Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response

1 reference

12 December 2020

How many specific B cells are needed to protect against a virus?

1 reference

12 December 2020

Isolation of high affinity human antibodies directly from large synthetic repertoires.

1 reference

12 December 2020

The synergy between combinatorial chemistry and high-throughput screening.

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12 December 2020

Combichem and chemoinformatics.

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12 December 2020

In vitro antibody maturation. Improvement of a high affinity, neutralizing antibody against IL-1 beta.

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12 December 2020

Identifiers

DOI

10.1038/NBT.1694

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28 July 2017

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