(Q33731216)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

title

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Katherine M Hannan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Carleen Cullinane

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Jeannine Diesch

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Amee George

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Jaclyn E Quin

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Simon Harrison

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

James D Rozario

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Stuart M Pitson

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Johannes Zuber

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Ricky W Johnstone

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Mark A. Dawson

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Grant McArthur

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Rick Pearson

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Ross D. Hannan

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

author name string

Nadine Hein

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Nhu-Y N Nguyen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Chun Yew Fong

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Meaghan Wall

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Megan Pavy

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Jennifer R Devlin

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Inge Verbrugge

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Adele Baker

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Denis Drygin

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Jason A Powell

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Mark A Guthridge

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Andrew Wei

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Jirawas Sornkom

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Elaine Sanij

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Gretchen Poortinga

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

language of work or name

English

0 references

publication date

10 March 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

volume

129

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

issue

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

page(s)

2882-2895

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

5 April 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

BET inhibitor resistance emerges from leukaemia stem cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Downregulation of rRNA transcription triggers cell differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Sensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RARα promoter region

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

The nucleolus stress response is coupled to an ATR-Chk1-mediated G2 arrest

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

The pathogenesis of mixed-lineage leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

The nucleolus under stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Pharmacological activation of the p53 pathway in haematological malignancies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Mouse models of human AML accurately predict chemotherapy response

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Mapping and quantifying mammalian transcriptomes by RNA-Seq

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Mutated and non-mutated TP53 as targets in the treatment of leukaemia.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Inhibition of nucleoplasmic transcription and the translation of rapidly labeled nuclear proteins by low concentrations of actinomycin D in vivo. Proposed role of messenger RNA in ribosomal RNA transcription

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5445570

Biosynthesis of Ribosomal RNA in Nucleoli Regulates Pluripotency and Differentiation Ability of Pluripotent Stem Cells

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28283481

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2016-05-718171

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28283481%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

PubMed publication ID

28283481

1 reference