(Q33732761)

29 July 2017

1 reference

title

Senescent cells: a novel therapeutic target for aging and age-related diseases (English)

1 reference

29 July 2017

R M Naylor

1

1 reference

29 July 2017

D J Baker

series ordinal

2

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29 July 2017

J M van Deursen

series ordinal

3

1 reference

29 July 2017

language of work or name

English

0 references

publication date

5 December 2012

1 reference

Clinical Pharmacology & Therapeutics

29 July 2017

published in

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29 July 2017

volume

93

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29 July 2017

issue

1

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29 July 2017

page(s)

105-116

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Identification, proliferation, and differentiation of adult Leydig stem cells

29 July 2017

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21 June 2018

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21 June 2018

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

21 June 2018

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Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype

21 June 2018

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p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

21 June 2018

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Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates.

21 June 2018

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Four faces of cellular senescence.

21 June 2018

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Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

21 June 2018

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Cellular senescence controls fibrosis in wound healing

21 June 2018

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Fat tissue, aging, and cellular senescence

21 June 2018

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Inflammatory networks during cellular senescence: causes and consequences

21 June 2018

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Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status

21 June 2018

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A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen

21 June 2018

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The senescence-associated secretory phenotype: the dark side of tumor suppression

21 June 2018

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21 June 2018

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Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

21 June 2018

1 reference

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Short telomeres are a risk factor for idiopathic pulmonary fibrosis

21 June 2018

1 reference

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Whole chromosome instability and cancer: a complex relationship

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Cancer and ageing: convergent and divergent mechanisms

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

The common biology of cancer and ageing

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Cellular senescence: when bad things happen to good cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

The intersection of cancer and aging: establishing the need for breast cancer rehabilitation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

p53 in health and disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Cancer metastasis: building a framework

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Chronic health conditions in adult survivors of childhood cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Incidence and prevalence of idiopathic pulmonary fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Cellular senescence in the glaucomatous outflow pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Idiopathic pulmonary fibrosis: challenges and opportunities for the clinician and investigator

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Ink4a/Arf expression is a biomarker of aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

The serial cultivation of human diploid cell strains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Alzheimer Disease in the US Population

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Tumor cell senescence in cancer treatment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Premature aging in mice deficient in DNA repair and transcription

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Characterization of regulatory elements on the promoter region of p16(INK4a) that contribute to overexpression of p16 in senescent fibroblasts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Deletion of Ku86 causes early onset of senescence in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

The INK4A/ARF locus and its two gene products

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Hayflick, his limit, and cellular ageing.

21 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.193

Ink4a/Arf expression is a biomarker of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.193

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.193

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.193

Fatigue and proinflammatory cytokine activity in breast cancer survivors

21 January 2018

1 reference

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Inflammatory markers and physical performance in older persons: the InCHIANTI study

21 January 2018

1 reference

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Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.193

Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.193

RPE cell senescence: a key contributor to age-related macular degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.193

The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Cigarette smoke induces senescence in alveolar epithelial cells

30 October 2018

1 reference

12 December 2020

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

1 reference

12 December 2020

A crucial role for adipose tissue p53 in the regulation of insulin resistance

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12 December 2020

The role of chondrocyte senescence in osteoarthritis

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12 December 2020

Identifiers

DOI

10.1038/CLPT.2012.193

1 reference

29 July 2017

1 reference

29 July 2017

1 reference