(Q33737486)

29 July 2017

title

Functional characterization of FLT3 receptor signaling deregulation in acute myeloid leukemia by single cell network profiling (SCNP). (English)

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29 July 2017

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acute myeloid leukemia

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9

Wendy J Fantl

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29 July 2017

David B Rosen

1

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29 July 2017

Mark D Minden

2

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29 July 2017

Steven M Kornblau

3

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29 July 2017

Aileen Cohen

4

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29 July 2017

Urte Gayko

5

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29 July 2017

Santosh Putta

6

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29 July 2017

John Woronicz

7

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29 July 2017

Erik Evensen

8

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29 July 2017

Alessandra Cesano

10

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29 July 2017

language of work or name

English

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publication date

27 October 2010

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29 July 2017

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29 July 2017

volume

5

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29 July 2017

issue

10

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29 July 2017

page(s)

e13543

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Creative Commons Attribution 4.0 International

29 July 2017

copyright license

start time

27 October 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome.

21 June 2018

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21 June 2018

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Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

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Deregulation of signaling pathways in acute myeloid leukemia

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Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

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21 June 2018

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Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor

21 June 2018

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The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia

21 June 2018

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Hematopoietic cytokine receptor signaling

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ABC transporter expression in hematopoietic stem cells and the role in AML drug resistance.

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Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders

21 June 2018

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Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling

21 June 2018

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Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia

21 June 2018

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Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

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No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials.

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Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

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Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

21 June 2018

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Causal protein-signaling networks derived from multiparameter single-cell data

21 June 2018

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AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.

21 June 2018

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Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics

21 June 2018

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Statistics review 13: receiver operating characteristic curves

21 June 2018

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Single cell profiling of potentiated phospho-protein networks in cancer cells.

21 June 2018

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Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

21 June 2018

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Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line

21 June 2018

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Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

21 June 2018

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

The meaning and use of the area under a receiver operating characteristic (ROC) curve

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

A method of comparing the areas under receiver operating characteristic curves derived from the same cases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013543

FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013543

BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid leukemia patients with normal cytogenetics: prognostic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013543

Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013543

AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013543

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013543

Mapping normal and cancer cell signalling networks: towards single-cell proteomics

21 January 2018

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Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013543

Interleukin-27 directly induces differentiation in hematopoietic stem cells

21 January 2018

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Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations.

21 January 2018

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ABCB1 and ABCG2 proteins, their functional activity and gene expression in concert with drug sensitivity of leukemia cells.

21 January 2018

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Robust Tests for the Equality of Variances

21 January 2018

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Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia

21 January 2018

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Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965086

Expression and Signal Transduction of the FLT3 Tyrosine Kinase Receptor

30 October 2018

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Prognostic significance of FLT3 ITD and D835 mutations in AML patients

21 January 2018

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12 December 2020

Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia

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12 December 2020

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

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12 December 2020

The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro

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12 December 2020

Flt3 ligand induces proliferation of quiescent human bone marrow CD34+CD38- cells and maintains progenitor cells in vitro

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12 December 2020

IL-4, IL-10 and IL-13 in acute myelogenous leukemia

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12 December 2020

Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan

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12 December 2020

Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia

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12 December 2020

Tyrosine kinases as targets for cancer therapy

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12 December 2020

Expression of pSTAT5 predicts FLT3 internal tandem duplications in acute myeloid leukemia

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12 December 2020

10.1371/JOURNAL.PONE.0013543

Identifiers

DOI

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29 July 2017

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29 July 2017

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