(Q33742766)

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Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24737137%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24737137%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

2

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14 March 2020

Gergely L Lukacs

6

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14 March 2020

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Puay-Wah Phuan

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14 March 2020

Walter E Finkbeiner

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Walter E Finkbeiner

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14 March 2020

author name string

Joseph Tan

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14 March 2020

Ariel Roldan

4

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14 March 2020

A S Verkman

7

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14 March 2020

publication date

15 April 2014

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14 March 2020

Molecular Pharmacology

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14 March 2020

86

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14 March 2020

1

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14 March 2020

42-51

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14 March 2020

Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Novel pharmacological strategies to treat cystic fibrosis.

1 reference

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21 June 2018

Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA.

1 reference

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21 June 2018

Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Fixing cystic fibrosis by correcting CFTR domain assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Cystic fibrosis: a mucosal immunodeficiency syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Emergent properties of proteostasis in managing cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

2-Aminothiazoles as therapeutic leads for prion diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Therapeutics development for cystic fibrosis: a successful model for a multisystem genetic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Peripheral protein quality control removes unfolded CFTR from the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Influence of cell background on pharmacological rescue of mutant CFTR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Cooperative assembly and misfolding of CFTR domains in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

CFTR function and prospects for therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

The ABC protein turned chloride channel whose failure causes cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Towards an in vitro model of cystic fibrosis small airway epithelium: characterisation of the human bronchial epithelial cell line CFBE41o-.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

Assembly of functional CFTR chloride channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

21 June 2018

A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases

1 reference

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21 June 2018

New concepts of the pathogenesis of cystic fibrosis lung disease

1 reference

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21 June 2018

Green fluorescent protein-based halide indicators with improved chloride and iodide affinities

1 reference

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21 June 2018

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

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21 June 2018

Genotype and phenotype in cystic fibrosis

1 reference

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21 June 2018

Differentiated structure and function of cultures from human tracheal epithelium

1 reference

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21 June 2018

Corrector VX-809 stabilizes the first transmembrane domain of CFTR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4054004

30 October 2018

Human nasal and tracheo-bronchial respiratory epithelial cell culture

1 reference

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30 October 2018

Aminothiazoles as γ-secretase modulators.

1 reference

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30 October 2018

Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

1 reference

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30 October 2018

Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: a combined medicinal chemistry, NMR and computational chemistry approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/24737137

12 December 2020

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10.1124/MOL.114.092478

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Europe PubMed Central

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14 March 2020

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Europe PubMed Central

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14 March 2020

PubMed publication ID

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Europe PubMed Central

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14 March 2020

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