(Q33743756)

29 July 2017

5 references

19 September 2019

13 December 2019

15 December 2019

21 December 2019

31 October 2020

Adnectins: engineered target-binding protein therapeutics (English)

1 reference

biomedical investigative technique

29 July 2017

main subject

1 reference

19 September 2019

1 reference

13 December 2019

1 reference

15 December 2019

1 reference

21 December 2019

1 reference

31 October 2020

D Lipovsek

1

1 reference

29 July 2017

publication date

10 November 2010

1 reference

Protein Engineering Design and Selection

29 July 2017

1 January 2011

5 references

19 September 2019

13 December 2019

15 December 2019

21 December 2019

31 October 2020

6 references

29 July 2017

19 September 2019

13 December 2019

15 December 2019

21 December 2019

31 October 2020

24

1 reference

29 July 2017

issue

1-2

1 reference

29 July 2017

page(s)

3-9

1 reference

Creative Commons Attribution-NonCommercial 2.5 Generic

29 July 2017

copyright license

5 references

19 September 2019

13 December 2019

15 December 2019

21 December 2019

Stability and CDR composition biases enrich binder functionality landscapes

31 October 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffold

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

FN3: a new protein scaffold reaches the clinic

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Engineered protein scaffolds as next-generation antibody therapeutics.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Phage display derived therapeutic antibodies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein Interfaces

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

mRNA display selection of a high-affinity, modification-specific phospho-IkappaBalpha-binding fibronectin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Human monoclonal antibodies from transgenic mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

High-affinity single-domain binding proteins with a binary-code interface

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Isolating and engineering human antibodies using yeast surface display

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III domain and selected by yeast surface display: molecular convergence with single-domain camelid and shark antibodies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Design, expression, and stability of a diverse protein library based on the human fibronectin type III domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

High-affinity fragment complementation of a fibronectin type III domain and its application to stability enhancement

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Antibody mimics based on human fibronectin type three domain engineered for thermostability and high-affinity binding to vascular endothelial growth factor receptor two.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Engineered proteins as specific binding reagents.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Molecular recognition by a binary code

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Applications of ribosome display to antibody drug discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

In-vitro protein evolution by ribosome display and mRNA display

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Molecular recognition properties of FN3 monobodies that bind the Src SH3 domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Domain antibodies: proteins for therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

The fibronectin type III domain as a scaffold for novel binding proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Crystal structure of the tenth type III cell adhesion module of human fibronectin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Continuous cultures of fused cells secreting antibody of predefined specificity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Exploring the potential of the monobody scaffold: effects of loop elongation on the stability of a fibronectin type III domain

28 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ097

Strategies and challenges for the next generation of therapeutic antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ097

Antibodies from phage antibody libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ097

Crystallographic structure of an intact IgG1 monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ097

Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ097

Directed evolution of high-affinity antibody mimics using mRNA display

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ097

Stabilization of a fibronectin type III domain by the removal of unfavorable electrostatic interactions on the protein surface

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003446

Two proteins with the same structure respond very differently to mutation: the role of plasticity in protein stability

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21068165

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

3 Protein engineering of single-chain Fv analogs and fusion proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21068165

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21068165

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/PROTEIN/GZQ097

1 reference

29 July 2017

1 reference

29 July 2017

1 reference