(Q33747010)

29 July 2017

title

Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid Pharmacophore (English)

1 reference

29 July 2017

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Claudio Trapella

3

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John L Neumeyer

object named as

John L Neumeyer

8

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Severo Salvadori

object named as

Severo Salvadori

2

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author name string

Gianfranco Balboni

1

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29 July 2017

Brian I Knapp

4

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29 July 2017

Jean M Bidlack

5

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29 July 2017

Lawrence H Lazarus

6

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29 July 2017

Xuemei Peng

7

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29 July 2017

publication date

1 February 2010

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ACS Chemical Neuroscience

29 July 2017

published in

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29 July 2017

volume

1

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29 July 2017

issue

2

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29 July 2017

page(s)

155-164

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Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile

29 July 2017

cites work

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21 June 2018

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Design of multivalent ligand targeting G-protein-coupled receptors

21 June 2018

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Pharmacological characterization of ATPM [(-)-3-aminothiazolo[5,4-b]-N-cyclopropylmethylmorphinan hydrochloride], a novel mixed kappa-agonist and mu-agonist/-antagonist that attenuates morphine antinociceptive tolerance and heroin self-administratio

21 June 2018

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Role of delta opioid efficacy as a determinant of mu/delta opioid interactions in rhesus monkeys

21 June 2018

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In vivo trafficking of endogenous opioid receptors

21 June 2018

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The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

21 June 2018

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COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia

21 June 2018

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Comparing analgesia and mu-opioid receptor internalization produced by intrathecal enkephalin: requirement for peptidase inhibition

21 June 2018

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Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.

21 June 2018

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The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists

21 June 2018

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Subtleties of structure-agonist versus antagonist relationships of opioid peptides and peptidomimetics

21 June 2018

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An antisense oligodeoxynucleotide to the delta opioid receptor (DOR-1) inhibits morphine tolerance and acute dependence in mice

21 June 2018

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Delta opioidmimetic antagonists: prototypes for designing a new generation of ultraselective opioid peptides.

21 June 2018

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Reactivity of bovine blood coagulation factor IXa beta, factor Xa beta, and factor XIa toward fluorogenic peptides containing the activation site sequences of bovine factor IX and factor X.

21 June 2018

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 June 2018

1 reference

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Morphine tolerance increases mu-noncompetitive delta binding sites

21 June 2018

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Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists

21 June 2018

1 reference

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The delta receptor is involved in sufentanil-induced respiratory depression--opioid subreceptors mediate different effects

21 June 2018

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2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

21 June 2018

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30 October 2018

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Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors

30 October 2018

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Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843921

Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843921

Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843921

Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice

30 October 2018

1 reference

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5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.

30 October 2018

1 reference

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Relative efficacy of the opioid antagonist, naltrexone, on the initiation and promotion phases of rat mammary carcinogenesis.

30 October 2018

1 reference

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30 October 2018

1 reference

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Selective opioid dipeptides

30 October 2018

1 reference

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Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice

30 October 2018

1 reference

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Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats

30 October 2018

1 reference

12 December 2020

Naltrexone modulates tumor response in mice with neuroblastoma

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12 December 2020

Opiate withdrawal intensity correlates with the presence of DSLET high-affinity binding

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12 December 2020

New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties

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12 December 2020

Chronic morphine treatment increases the number, but decreases the affinity of [3H]-U69,593 binding sites in the rat heart

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12 December 2020

Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation

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12 December 2020

Identifiers

DOI

10.1021/CN900025J

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29 July 2017

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29 July 2017

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