(Q33755350)

29 July 2017

title

Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence (English)

1 reference

29 July 2017

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5

Derek B Sant'Angelo

1 reference

29 July 2017

Woelsung Yi

1

1 reference

29 July 2017

Nilufer P Seth

2

1 reference

29 July 2017

Tom Martillotti

3

1 reference

29 July 2017

Kai W Wucherpfennig

4

1 reference

29 July 2017

Lisa K Denzin

6

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29 July 2017

language of work or name

English

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publication date

1 April 2010

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Journal of Clinical Investigation

29 July 2017

published in

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29 July 2017

volume

120

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29 July 2017

issue

4

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29 July 2017

page(s)

1324-1336

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Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

29 July 2017

cites work

1 reference

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Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues

21 June 2018

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The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

21 June 2018

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Insulin as an autoantigen in NOD/human diabetes

21 June 2018

1 reference

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B cells in the spotlight: innocent bystanders or major players in the pathogenesis of type 1 diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Central tolerance: good but imperfect

21 June 2018

1 reference

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Antigen processing by autoreactive B cells promotes determinant spreading

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Right place, right time, right peptide: DO keeps DM focused

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

A comprehensive review of interventions in the NOD mouse and implications for translation

21 June 2018

1 reference

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The NOD mouse: a model of immune dysregulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Back to central tolerance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Lysosomal cysteine proteases regulate antigen presentation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Tolerogenic dendritic cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Germinal center B cells regulate their capability to present antigen by modulation of HLA-DO.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

The cell biology of antigen presentation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

In vivo and in vitro modulation of HLA-DM and HLA-DO is induced by B lymphocyte activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Relaxed DM requirements during class II peptide loading and CD4+ T cell maturation in BALB/c mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

The initiation of autoimmune diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Antigen processing: HLA-DO--a hitchhiking inhibitor of HLA-DM.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Altered antigen presentation in mice lacking H2-O

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

A mechanism for the major histocompatibility complex-linked resistance to autoimmunity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Negative regulation by HLA-DO of MHC class II-restricted antigen processing

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Antigen presentation and T cell development in H2-M-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

T-lymphocyte clone specific for pancreatic islet antigen

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Regulated expression and function of CD11c/CD18 integrin on human B lymphocytes. Relation between attachment to fibrinogen and triggering of proliferation through CD11c/CD18.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Ex Vivo Analysis of Thymic CD4 T Cells in Nonobese Diabetic Mice with Tetramers Generated from I-Ag7/Class II-Associated Invariant Chain Peptide Precursors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Lymphoid organs contain diverse cells expressing self-molecules

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

Mouse monoclonal antibodies against rat major histocompatibility antigens. Two Ia antigens and expression of Ia and class I antigens in rat thymus

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846047

DM loss in k haplotype mice reveals isotype-specific chaperone requirements

30 October 2018

1 reference

12 December 2020

Analysis of H2-O influence on antigen presentation by B cells

1 reference

12 December 2020

Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation

1 reference

12 December 2020

Inhibition of proliferation of MIs- and Ia-reactive cloned T cells by a monoclonal antibody against a determinant shared by I-A and I-E

1 reference

12 December 2020

Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

1 reference

12 December 2020

Following a diabetogenic T cell from genesis through pathogenesis

1 reference

12 December 2020

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders

1 reference

12 December 2020

Insulin-dependent diabetes mellitus

1 reference

12 December 2020

Distinct peptide loading pathways for MHC class II molecules associated with alternative Ii chain isoforms

1 reference

12 December 2020

MHC class II expression in double mutant mice lacking invariant chain and DM functions

1 reference

12 December 2020

BALB/c invariant chain mutant mice display relatively efficient maturation of CD4+ T cells in the periphery and secondary proliferative responses elicited upon peptide challenge

1 reference

12 December 2020

Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation

1 reference

12 December 2020

H2-O expression in primary dendritic cells

1 reference

12 December 2020

Loss of invariant chain protects nonobese diabetic mice against type 1 diabetes

1 reference

12 December 2020

Expression patterns of H2-O in mouse B cells and dendritic cells correlate with cell function

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI40220

1 reference

29 July 2017

1 reference

29 July 2017

1 reference