(Q33756522)

English

How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes.

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22 March 2020

How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28580193%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Romas J. Kazlauskas

2

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22 March 2020

author name string

Alissa Rauwerdink

1

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22 March 2020

publication date

9 September 2015

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22 March 2020

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22 March 2020

5

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22 March 2020

10

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22 March 2020

6153-6176

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Europe PubMed Central

PMC publication ID

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22 March 2020

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1 reference

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Molecular Basis of the General Base Catalysis of an / -Hydrolase Catalytic Triad

1 reference

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Origin of the Proton-transfer Step in the Cofactor-free (1H)-3-Hydroxy-4-oxoquinaldine 2,4-Dioxygenase: EFFECT OF THE BASICITY OF AN ACTIVE SITE HIS RESIDUE

1 reference

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A Substrate-Assisted Mechanism of Nucleophile Activation in a Ser–His–Asp Containing C–C Bond Hydrolase

1 reference

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Single residues dictate the co-evolution of dual esterases: MCP hydrolases from the α/β hydrolase family

1 reference

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Crystal structures of E. coli native MenH and two active site mutants

1 reference

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1 reference

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The solution of nitrogen inversion in amidases.

1 reference

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New structural motif for carboxylic acid perhydrolases.

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High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism forN-acyl homoserine lactonase

1 reference

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21 June 2018

ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions

1 reference

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21 June 2018

Hydroxynitrile Lyases with α/β-Hydrolase Fold: Two Enzymes with Almost Identical 3D Structures but Opposite Enantioselectivities and Different Reaction Mechanisms

1 reference

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1 reference

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Emergent Decarboxylase Activity and Attenuation of α/β-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in Tomato

1 reference

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21 June 2018

Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad

1 reference

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21 June 2018

Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity

1 reference

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21 June 2018

Different active-site loop orientation in serine hydrolases versus acyltransferases

1 reference

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21 June 2018

X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger

1 reference

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21 June 2018

Switching from an esterase to a hydroxynitrile lyase mechanism requires only two amino acid substitutions

1 reference

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1 reference

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21 June 2018

The alpha/beta-hydrolase fold 3DM database (ABHDB) as a tool for protein engineering

1 reference

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Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture

1 reference

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1 reference

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Enzyme promiscuity: a mechanistic and evolutionary perspective

1 reference

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1 reference

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Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the / -hydrolase fold

1 reference

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21 June 2018

Catalytic mechanism of SHCHC synthase in the menaquinone biosynthesis of Escherichia coli: identification and mutational analysis of the active site residues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

21 June 2018

Alpha/beta hydrolase fold: an update

1 reference

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Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle

1 reference

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21 June 2018

Atomic resolution crystal structures and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysis

1 reference

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21 June 2018

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1 reference

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A single amino acid change is responsible for evolution of acyltransferase specificity in bacterial methionine biosynthesis

1 reference

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X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation

1 reference

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Ohno's dilemma: evolution of new genes under continuous selection

1 reference

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21 June 2018

Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

21 June 2018

Structure of a novel enzyme that catalyzes acyl transfer to alcohols in aqueous conditions

1 reference

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21 June 2018

The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad

1 reference

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21 June 2018

Enzyme promiscuity: mechanism and applications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

21 June 2018

Structure and action of a C-C bond cleaving alpha/beta-hydrolase involved in nicotine degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

21 June 2018

Degrees of difficulty of water-consuming reactions in the absence of enzymes

1 reference

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21 June 2018

Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta

1 reference

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21 June 2018

Fast carbon-carbon bond formation by a promiscuous lipase

1 reference

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21 June 2018

An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans

1 reference

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21 June 2018

Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases

1 reference

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21 June 2018

Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity

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Diverse catalytic activities in the alphabeta-hydrolase family of enzymes: activation of H2O, HCN, H2O2, and O2.

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21 June 2018

Covalent reaction intermediate revealed in crystal structure of the Geobacillus stearothermophilus carboxylesterase Est30.

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21 June 2018

Reaction mechanism of hydroxynitrile lyases of the alpha/beta-hydrolase superfamily: the three-dimensional structure of the transient enzyme-substrate complex certifies the crucial role of LYS236.

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21 June 2018

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21 June 2018

ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins

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Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV

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21 June 2018

Alpha/Beta-hydrolase fold enzymes: structures, functions and mechanisms

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21 June 2018

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21 June 2018

Of barn owls and bankers: a lush variety of alpha/beta hydrolases

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21 June 2018

Catalytic promiscuity and the evolution of new enzymatic activities

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21 June 2018

Catalytic triads and their relatives

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21 June 2018

Prolyl endopeptidase

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Fusarium solani cutinase is a lipolytic enzyme with a catalytic serine accessible to solvent

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21 June 2018

The alpha/beta hydrolase fold

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21 June 2018

Purification of acetyl coenzyme A: deacetylacephalosporin C O-acetyltransferase from Acremonium chrysogenum

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21 June 2018

Evolution of enzyme function and the development of catalytic efficiency

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The characterization of multiple forms of kynurenine formidase in Drosophila melanogaster

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21 June 2018

Enhancing the Acyltransferase Activity of Candida antarctica Lipase A by Rational Design.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Substrate-assisted O2 activation in a cofactor-independent dioxygenase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

The catalytic serine of meta-cleavage product hydrolases is activated differently for C-O bond cleavage than for C-C bond cleavage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Promiscuous esterase activities of the C-C hydrolases from Dyella ginsengisoli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Converting an esterase into an epoxide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Direct epoxidation in Candida antarctica lipase B studied by experiment and theory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an alpha/beta-hydrolase fold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Catalytic role for arginine 188 in the C-C hydrolase catalytic mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Hydrolase-catalyzed Michael addition of imidazoles to acrylic monomers in organic medium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Mirror-image packing in enantiomer discrimination molecular basis for the enantioselectivity of B.cepacia lipase toward 2-methyl-3-phenyl-1-propanol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

The structure of the C-C bond hydrolase MhpC provides insights into its catalytic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Exploring the active-site of a rationally redesigned lipase for catalysis of Michael-type additions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Dioxygenases without requirement for cofactors and their chemical model reaction: compulsory order ternary complex mechanism of 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase involving general base catalysis by histidine 251 and single-electron oxidat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Catalytic promiscuity in biocatalysis: using old enzymes to form new bonds and follow new pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Lipase catalysed Michael addition of secondary amines to acrylonitrile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

The crystal structure of a (-) gamma-lactamase from an Aureobacterium species reveals a tetrahedral intermediate in the active site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

A molecular mechanism of enantiorecognition of tertiary alcohols by carboxylesterases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Role of Acinetobacter calcoaceticus 3,4-dihydrocoumarin hydrolase in oxidative stress defence against peroxoacids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Carbon-carbon bonds by hydrolytic enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

The lipase/acyltransferase from Candida parapsilosis: molecular cloning and characterization of purified recombinant enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455348

30 October 2018

Esterases with an Introduced Amidase-Like Hydrogen Bond in the Transition State Have Increased Amidase Specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/28580193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis for the enhanced lipase-catalyzed N-acylation of 1-phenylethanamine with methoxyacetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/28580193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Revised molecular basis of the promiscuous carboxylic acid perhydrolase activity in serine hydrolases

1 reference

https://pubmed.ncbi.nlm.nih.gov/28580193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a serine hydrolase as a key determinant in the microbial degradation of polychlorinated biphenyls

1 reference

https://pubmed.ncbi.nlm.nih.gov/28580193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytic promiscuity in the alpha/beta-hydrolase superfamily: hydroxamic acid formation, C--C bond formation, ester and thioester hydrolysis in the C--C hydrolase family

1 reference

https://pubmed.ncbi.nlm.nih.gov/28580193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Racemase activity of B. cepacia lipase leads to dual-function asymmetric dynamic kinetic resolution of α-aminonitriles

1 reference

https://pubmed.ncbi.nlm.nih.gov/28580193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate-induced conformational change and isomerase activity of dienelactone hydrolase and its site-specific mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/28580193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of lipases and esterases towards tertiary alcohols: insights into structure-function relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/28580193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Grease pit chemistry exposed

1 reference

https://pubmed.ncbi.nlm.nih.gov/28580193

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACSCATAL.5B01539

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28580193%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28580193%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28580193%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

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