(Q33760068)

29 July 2017

title

Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis (English)

1 reference

29 July 2017

1 reference

Gehua Zhen

1

1 reference

29 July 2017

Xu Cao

series ordinal

2

1 reference

29 July 2017

publication date

15 April 2014

1 reference

Trends in Pharmacological Sciences

29 July 2017

published in

1 reference

29 July 2017

volume

35

1 reference

29 July 2017

issue

5

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29 July 2017

page(s)

227-236

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Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice

29 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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The TGF-β co-receptor, CD109, promotes internalization and degradation of TGF-β receptors.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads

21 June 2018

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Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling

21 June 2018

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Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice

21 June 2018

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Chondrogenesis, joint formation, and articular cartilage regeneration.

21 June 2018

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Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized.

21 June 2018

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21 June 2018

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Roles of TGF-beta family signaling in stem cell renewal and differentiation

21 June 2018

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Morphogenetic and regulatory mechanisms during developmental chondrogenesis: new paradigms for cartilage tissue engineering

21 June 2018

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Parathyroid hormone signaling through low-density lipoprotein-related protein 6

21 June 2018

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21 June 2018

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Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation

21 June 2018

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Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship

21 June 2018

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Denosumab: RANKL inhibition in the management of bone loss

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Boning up on ephrin signaling

21 June 2018

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A 2 yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients

21 June 2018

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Betaglycan induces TGF-beta signaling in a ligand-independent manner, through activation of the p38 pathway

21 June 2018

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21 June 2018

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The control of chondrogenesis

21 June 2018

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Cell-surface co-receptors: emerging roles in signaling and human disease

21 June 2018

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Autocrine transforming growth factor-beta regulation of hematopoiesis: many outcomes that depend on the context

21 June 2018

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How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow

21 June 2018

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

21 June 2018

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A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2

21 June 2018

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An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis

21 June 2018

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Heterozygous TGFBR2 mutations in Marfan syndrome

21 June 2018

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Osteoarthritis: symptoms, signs and source of pain

21 June 2018

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An update on bisphosphonates

21 June 2018

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Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis?

21 June 2018

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Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

21 June 2018

1 reference

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Mediation of interleukin-1beta-induced transforming growth factor beta1 expression by activator protein 4 transcription factor in primary cultures of bovine articular chondrocytes: possible cooperation with activator protein 1.

21 June 2018

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Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome

21 June 2018

1 reference

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Making sense of latent TGFbeta activation

21 June 2018

1 reference

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Mesenchymal stem cells. A potential source for skeletal repair

21 June 2018

1 reference

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Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation

21 June 2018

1 reference

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The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

21 June 2018

1 reference

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The first stage of transforming growth factor beta1 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3)

21 June 2018

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The involvement of beta1 integrin in the modulation by collagen of chondrocyte-response to transforming growth factor-beta1.

21 June 2018

1 reference

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Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability

21 June 2018

1 reference

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TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

21 June 2018

1 reference

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Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice

21 June 2018

1 reference

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Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease.

21 June 2018

1 reference

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Bone resorption by osteoclasts

21 June 2018

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Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology

21 June 2018

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

21 June 2018

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Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1

21 June 2018

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Alendronate reduces adhesion of human osteoclast-like cells to bone and bone protein-coated surfaces

21 June 2018

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Decrease of cartilage transforming growth factor-beta receptor II expression in the rabbit experimental osteoarthritis--potential role in cartilage breakdown.

21 June 2018

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Swelling and fibronectin accumulation in articular cartilage explants after cyclical impact

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Bisphosphonates: mechanisms of action

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Evolution of the transforming growth factor-beta superfamily

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Transforming growth factor beta

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Transforming growth factor beta type 1 binds to collagen IV of basement membrane matrix: implications for development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

21 June 2018

Mesenchymal stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Transforming growth factor-beta in calf articular cartilage organ cultures: synthesis and distribution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Release of transforming growth factor-beta 1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Alendronate treatment for hip osteoarthritis: prospective randomized 2-year trial

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects in vivo

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Mechanosensation and transduction in osteocytes.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Regulatory mechanism of transforming growth factor beta receptor type II degradation by interleukin-1 in primary chondrocytes.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Genetics of osteoarthritis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Endoglin differentially regulates TGF-β-induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Mechanotransduction of bovine articular cartilage superficial zone protein by transforming growth factor beta signaling

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

The relationship of antiresorptive drug use to structural findings and symptoms of knee osteoarthritis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Lysophospholipid regulates release and activation of latent TGF-beta1 from chondrocyte extracellular matrix

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Latent TGF-beta1 activation by platelets

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Expression and action of transforming growth factor beta (TGFbeta1, TGFbeta2, and TGFbeta3) during embryonic rat testis development.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

The importance of subchondral bone in osteoarthrosis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058854

Authentic matrix vesicles contain active metalloproteases (MMP). a role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta

30 October 2018

1 reference

12 December 2020

Global analyses of gene expression in early experimental osteoarthritis

1 reference

12 December 2020

Potential mechanisms for the plasmin-mediated release and activation of latent transforming growth factor-beta1 from the extracellular matrix of growth plate chondrocytes

1 reference

12 December 2020

Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental osteoarthritis

1 reference

12 December 2020

Differential upregulation of the three transforming growth factor beta isoforms in human osteoarthritic cartilage

1 reference

12 December 2020

Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence

1 reference

12 December 2020

Chondroprotective effect of alendronate in a rabbit model of osteoarthritis

1 reference

12 December 2020

Fluid-induced shear stress stimulates chondrocyte proliferation partially mediated via TGF-beta1

1 reference

12 December 2020

Participation of transglutaminase in the activation of latent transforming growth factor beta1 in aging articular cartilage

1 reference

12 December 2020

Plasmin, substilisin-like endoproteases, tissue plasminogen activator, and urokinase plasminogen activator are involved in activation of latent TGF-beta 1 in human seminal plasma

1 reference

12 December 2020

Early elevation of transforming growth factor-beta, decorin, and biglycan mRNA levels during cartilage matrix restoration after mild proteoglycan depletion

1 reference

12 December 2020

Knee cartilage of spinal cord-injured patients displays progressive thinning in the absence of normal joint loading and movement

1 reference

12 December 2020

Perfusion Abnormalities in Subchondral Bone Associated with Marrow Edema, Osteoarthritis, and Avascular Necrosis

1 reference

12 December 2020

Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor beta: role of furin convertase

1 reference

12 December 2020

The subchondral bone: a new frontier in articular cartilage repair

1 reference

12 December 2020

Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction

1 reference

12 December 2020

Targeting osteoclast-osteoblast communication

1 reference

12 December 2020

Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis

1 reference

12 December 2020

Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites

1 reference

12 December 2020

10.1016/J.TIPS.2014.03.005

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference