(Q33764044)

English

Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

phosphorylation

1 reference

based on heuristic

inferred from title

Alexander Wlodawer

7

object named as

Alexander Wlodawer

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Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Lisa M Miller Jenkins

1

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Europe PubMed Central

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29 July 2017

Ryo Hayashi

3

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Europe PubMed Central

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29 July 2017

Scott Cherry

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Joseph E Tropea

5

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Europe PubMed Central

PubMed publication ID

29 July 2017

Maria Miller

6

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Europe PubMed Central

PubMed publication ID

29 July 2017

Ettore Appella

8

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Europe PubMed Central

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29 July 2017

Sharlyn J Mazur

9

1 reference

Europe PubMed Central

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29 July 2017

Hiroshi Yamaguchi

2

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29 July 2017

language of work or name

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publication date

1 February 2009

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Europe PubMed Central

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29 July 2017

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Europe PubMed Central

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29 July 2017

48

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Europe PubMed Central

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29 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

1244-1255

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence

1 reference

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14 July 2018

Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

P53 promoter selection: choosing between life and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Outcomes of p53 activation--spoilt for choice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Structural details on mdm2-p53 interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Heat capacity in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Common effects of acidic activators on large-scale chromatin structure and transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

The N-terminal interferon-binding domain (IBiD) homology domain of p300 binds to peptides with homology to the p53 transactivation domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

The CBP/p300 TAZ1 domain in its native state is not a binding partner of MDM2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

DNA-dependent acetylation of p53 by the transcription coactivator p300.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Post-translational modifications and activation of p53 by genotoxic stresses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

CBP/p300 in cell growth, transformation, and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Synergistic activation of transcription by CBP and p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

How to measure and predict the molar absorption coefficient of a protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Temperature dependence of the hydrophobic interaction in protein folding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Contribution to the thermodynamics of protein folding from the reduction in water-accessible nonpolar surface area.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

14 July 2018

Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

30 October 2018

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848171

10 December 2018

Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19166313

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://pubmed.ncbi.nlm.nih.gov/19166313

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1 reference

https://pubmed.ncbi.nlm.nih.gov/19166313

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19166313

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19166313

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/19166313

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential recognition of phosphorylated transactivation domains of p53 by different p300 domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19166313

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19166313

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI801716H

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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