(Q40373998)

19 September 2017

title

Structural details on mdm2-p53 interaction (English)

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19 September 2017

Seung-Wook Chi

1

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19 September 2017

Si-Hyung Lee

2

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19 September 2017

Do-Hyoung Kim

3

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19 September 2017

Min-Jung Ahn

4

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19 September 2017

Jae-Sung Kim

5

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19 September 2017

Jin-Young Woo

6

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19 September 2017

Takuya Torizawa

7

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19 September 2017

Masatsune Kainosho

8

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19 September 2017

Kyou-Hoon Han

9

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19 September 2017

language of work or name

English

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publication date

13 September 2005

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Journal of Biological Chemistry

19 September 2017

published in

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19 September 2017

volume

280

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19 September 2017

issue

46

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19 September 2017

page(s)

38795-38802

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19 September 2017

cites work

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

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Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

21 January 2018

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Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

21 January 2018

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p53 contains large unstructured regions in its native state

21 January 2018

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Transactivation functions of the N-terminal domains of nuclear hormone receptors: protein folding and coactivator interactions

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Binding‐induced folding transitions in calpastatin subdomains A and C

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Preformed structural elements feature in partner recognition by intrinsically unstructured proteins

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Role of secondary structure in discrimination between constitutive and inducible activators

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21 January 2018

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NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain

21 January 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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Molecular mechanism of the interaction between MDM2 and p53.

21 January 2018

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Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes.

21 January 2018

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Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

21 January 2018

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The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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HIF-1 and mechanisms of hypoxia sensing

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Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

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Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.

21 January 2018

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Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

21 January 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

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Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage

21 January 2018

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21 January 2018

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Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

21 January 2018

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Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M508578200

1 reference

19 September 2017

1 reference