(Q33766526)

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Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice

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scholarly article

1 reference

Europe PubMed Central

29 July 2017

Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice (English)

1 reference

Europe PubMed Central

29 July 2017

author name string

Yao Zhang

1

1 reference

Europe PubMed Central

29 July 2017

Rong-Hong Ma

2

1 reference

Europe PubMed Central

29 July 2017

Xia-Chun Li

3

1 reference

Europe PubMed Central

29 July 2017

Jia-Yu Zhang

4

1 reference

Europe PubMed Central

29 July 2017

Hai-Rong Shi

5

1 reference

Europe PubMed Central

29 July 2017

Wei Wei

6

1 reference

Europe PubMed Central

29 July 2017

Dan-Ju Luo

7

1 reference

Europe PubMed Central

29 July 2017

Qun Wang

8

1 reference

Europe PubMed Central

29 July 2017

Jian-Zhi Wang

9

1 reference

Europe PubMed Central

29 July 2017

Gong-Ping Liu

10

1 reference

Europe PubMed Central

29 July 2017

publication date

17 June 2014

1 reference

Europe PubMed Central

29 July 2017

Frontiers in Aging Neuroscience

1 reference

Europe PubMed Central

29 July 2017

6

1 reference

Europe PubMed Central

29 July 2017

123

1 reference

Europe PubMed Central

29 July 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4060416/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Interactions between GSK3β and amyloid genes explain variance in amyloid burden

1 reference

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22 June 2018

Presenilin influences glycogen synthase kinase-3 β (GSK-3β) for kinesin-1 and dynein function during axonal transport

1 reference

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22 June 2018

Silencing PP2A inhibitor by lenti-shRNA interference ameliorates neuropathologies and memory deficits in tg2576 mice

1 reference

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22 June 2018

An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease

1 reference

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22 June 2018

Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP)

1 reference

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22 June 2018

Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI

1 reference

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22 June 2018

GSK3 and tau: two convergence points in Alzheimer's disease.

1 reference

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22 June 2018

A pivotal role of GSK-3 in synaptic plasticity.

1 reference

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22 June 2018

Roles of glycogen synthase kinase 3 in Alzheimer's disease

1 reference

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22 June 2018

GSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration

1 reference

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22 June 2018

Role of protein phosphatase 2A in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain

1 reference

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22 June 2018

The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons

1 reference

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22 June 2018

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology

1 reference

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22 June 2018

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

GSK-3beta is required for memory reconsolidation in adult brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Microtubule-associated protein tau in development, degeneration and protection of neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

LTP inhibits LTD in the hippocampus via regulation of GSK3beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

GSK-3 is essential in the pathogenesis of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Injection of okadaic acid into the meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Tau function and dysfunction in neurons: its role in neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

A system for stable expression of short interfering RNAs in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Adeno-associated virus effectively mediates conditional gene modification in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Phosphoprotein phosphatase activities in Alzheimer disease brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

22 June 2018

In Vitro Phosphorylation of the Cytoplasmic Domain of the Amyloid Precursor Protein by Glycogen Synthase Kinase-3β

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Tangling with hypothermia

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration.

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis.

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B.

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Alzheimer's disease research: scientific productivity and impact of the top 100 investigators in the field

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2014.00123

21 January 2018

Influence of intracerebroventricular administration of dopaminergic drugs on morphine state-dependent memory in the step-down passive avoidance test.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

30 October 2018

Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

30 October 2018

Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060416

30 October 2018

Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24987368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenic L392V mutation of presenilin 1 decreases the affinity to glycogen synthase kinase-3 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/24987368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/24987368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/24987368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/24987368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FNAGI.2014.00123

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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