(Q33767122)

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Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations

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scholarly article

1 reference

Europe PubMed Central

29 July 2017

Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations (English)

1 reference

Europe PubMed Central

29 July 2017

genome-wide association study

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Joseph Lachance

1

object named as

Joseph Lachance

1 reference

Europe PubMed Central

29 July 2017

publication date

10 December 2010

1 reference

Europe PubMed Central

29 July 2017

BMC Medical Genomics

1 reference

Europe PubMed Central

29 July 2017

3

1 reference

Europe PubMed Central

29 July 2017

57

1 reference

Europe PubMed Central

29 July 2017

https://scigraph.springernature.com/pub.10.1186/1755-8794-3-57

0 references

Ancestry and disease in the age of genomic medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

A Draft Sequence of the Neandertal Genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Genetic heterogeneity in human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Q&A: promise and pitfalls of genome-wide association studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

GWAS: heritability missing in action?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Rare variants create synthetic genome-wide associations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

A tutorial of the poisson random field model in population genetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Finding the missing heritability of complex diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Epistasis and its implications for personal genetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Site frequency spectra from genomic SNP surveys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Common genetic variation and human traits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Genome-wide QTL mapping for three traits related to teat number in a White Duroc x Erhualian pig resource population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Genetic mapping in human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Personal genomes: The case of the missing heritability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Estimates of natural selection due to protein tertiary structure inform the ancestry of biallelic loci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Natural selection on genes that underlie human disease susceptibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Worldwide population differentiation at disease-associated SNPs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

What can genome-wide association studies tell us about the genetics of common disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

A second generation human haplotype map of over 3.1 million SNPs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

The influence of recombination on human genetic diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Variants associated with common disease are not unusually differentiated in frequency across populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Ascertainment bias in studies of human genome-wide polymorphism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Determinants of the success of whole-genome association testing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Genome-wide association studies: theoretical and practical concerns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Reconstituting the frequency spectrum of ascertained single-nucleotide polymorphism data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Signatures of natural selection in the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

The allelic architecture of human disease genes: common disease-common variant... or not?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Linkage disequilibrium in humans: models and data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

dbSNP: the NCBI database of genetic variation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Estimating the age of alleles by use of intraallelic variability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Sampling theory for neutral alleles in a varying environment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

The age of a neutral mutant persisting in a finite population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Pairwise comparisons of mitochondrial DNA sequences in stable and exponentially growing populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017004

14 July 2018

Sample size requirements for matched case-control studies of gene-environment interaction

1 reference

https://api.crossref.org/works/10.1186%2F1755-8794-3-57

21 January 2018

Context dependence, ancestral misidentification, and spurious signatures of natural selection.

1 reference

https://api.crossref.org/works/10.1186%2F1755-8794-3-57

21 January 2018

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

1 reference

https://api.crossref.org/works/10.1186%2F1755-8794-3-57

21 January 2018

An open access database of genome-wide association results

1 reference

https://pubmed.ncbi.nlm.nih.gov/21143973

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomewide association studies--illuminating biologic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/21143973

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is the most frequent allele the oldest?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21143973

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The allelic spectra of common diseases may resemble the allelic spectrum of the full genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21143973

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1755-8794-3-57

1 reference

Europe PubMed Central

29 July 2017

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1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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