(Q33770059)

29 July 2017

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title

Mode of action of fluoroquinolones (English)

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29 July 2017

Hooper DC

1

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29 July 2017

1 January 1999

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29 July 2017

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29 July 2017

58 Suppl 2

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29 July 2017

6-10

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https://scigraph.springernature.com/pub.10.2165/00003495-199958002-00002

29 July 2017

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cites work

Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands

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12 December 2020

Type II DNA topoisomerases

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12 December 2020

Bipolar localization of Bacillus subtilis topoisomerase IV, an enzyme required for chromosome segregation

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12 December 2020

Escherichia coli K-12 Mutants Resistant to Nalidixic Acid: Genetic Mapping and Dominance Studies

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12 December 2020

The complete genome sequence of the gastric pathogen Helicobacter pylori

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12 December 2020

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

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12 December 2020

DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase-DNA complex

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12 December 2020

Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexes

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12 December 2020

Crystallization of Inhibitor Complexes of an N-Terminal 24 kDa Fragment of the DNA Gyrase B Protein

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12 December 2020

Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.

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12 December 2020

Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus

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12 December 2020

Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones

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12 December 2020

Quinolone-resistant mutations of the gyrA gene of Escherichia coli.

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12 December 2020

The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase.

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12 December 2020

Structure and mechanism of DNA topoisomerase II

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12 December 2020

Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones.

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12 December 2020

The DNA Gyrase-Quinolone Complex

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12 December 2020

Crystal structure of the breakage-reunion domain of DNA gyrase

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12 December 2020

Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV.

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12 December 2020

The mechanism of inhibition of topoisomerase IV by quinolone antibacterials.

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12 December 2020

The DNA cleavage reaction of DNA gyrase. Comparison of stable ternary complexes formed with enoxacin and CcdB protein

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12 December 2020

Limitations of plasmid complementation test for determination of quinolone resistance due to changes in the gyrase A protein and identification of conditional quinolone resistance locus

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12 December 2020

Conformational changes in DNA gyrase revealed by limited proteolysis.

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12 December 2020

gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli

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12 December 2020

DNA gyrase on the bacterial chromosome: possibility of two levels of action

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12 December 2020

New topoisomerase essential for chromosome segregation in E. coli.

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12 December 2020

Mechanism of quinolone action. A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV.

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12 December 2020

Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity

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12 December 2020

Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition

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12 December 2020

Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerases

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12 December 2020

Topoisomerase IV is a target of quinolones in Escherichia coli

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12 December 2020

Mechanisms of fluoroquinolone resistance

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12 December 2020

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

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12 December 2020

DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex.

1 reference

12 December 2020

Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete

1 reference

12 December 2020

Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.

1 reference

12 December 2020

DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae.

1 reference

12 December 2020

10.2165/00003495-199958002-00002

Identifiers

DOI

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Dimensions Publication ID

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1 reference

PubMed ID

10553698