(Q33780701)

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Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3

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30 January 2020

Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3 (English)

1 reference

Europe PubMed Central

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30 January 2020

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apoptotic process

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Christine E Brown

2

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30 January 2020

author name string

Fan Yang

1

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30 January 2020

Ralf Buettner

3

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30 January 2020

Michael Hedvat

4

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30 January 2020

Renate Starr

5

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30 January 2020

Anna Scuto

6

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30 January 2020

Anne Schroeder

7

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30 January 2020

Michael Jensen

8

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30 January 2020

Richard Jove

9

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30 January 2020

publication date

6 April 2010

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30 January 2020

Molecular Cancer Therapeutics

1 reference

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30 January 2020

9

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30 January 2020

4

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30 January 2020

953-962

1 reference

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30 January 2020

Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas

1 reference

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4 July 2018

New methods for direct delivery of chemotherapy for treating brain tumors.

1 reference

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4 July 2018

Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells

1 reference

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4 July 2018

Lessons learned in the development of targeted therapy for malignant gliomas.

1 reference

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4 July 2018

Molecularly targeted therapy for malignant glioma

1 reference

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4 July 2018

Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: a review of four phase I trials in patients with advanced refractory solid tumors

1 reference

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4 July 2018

Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy

1 reference

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4 July 2018

Molecular targets of glioma invasion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

Prognostic and clinical implication of IL-6 expression in glioblastoma multiforme

1 reference

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4 July 2018

Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer

1 reference

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4 July 2018

The role of IL-6 and STAT3 in inflammation and cancer

1 reference

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4 July 2018

The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

Genetic pathways to glioblastomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

Development of novel targeted therapies in the treatment of malignant glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852467

4 July 2018

The STATs of cancer--new molecular targets come of age

1 reference

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4 July 2018

Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis

1 reference

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4 July 2018

Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 1: growth factor and Ras signaling pathways

1 reference

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4 July 2018

Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

1 reference

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4 July 2018

Stat3 as an oncogene

1 reference

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4 July 2018

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

1 reference

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4 July 2018

The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation

1 reference

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30 October 2018

Sorafenib and sunitinib in the treatment of advanced non-small cell lung cancer.

1 reference

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30 October 2018

Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme

1 reference

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30 October 2018

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1 reference

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30 October 2018

Variations in the levels of the JAK/STAT and ShcA proteins in human brain tumors.

1 reference

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30 October 2018

Phase II study of sorafenib in patients with advanced hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371721

12 December 2020

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Identifiers

10.1158/1535-7163.MCT-09-0947

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Europe PubMed Central

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30 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20371721%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20371721%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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