(Q33781194)

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Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter

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Europe PubMed Central

PubMed publication ID

29 July 2017

Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

Peter J. Fuller

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Peter J Fuller

4

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Nicholas I Fleming

1

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Europe PubMed Central

PubMed publication ID

29 July 2017

Kevin C Knower

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

Kyren A Lazarus

3

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Europe PubMed Central

PubMed publication ID

29 July 2017

Evan R Simpson

5

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Europe PubMed Central

PubMed publication ID

29 July 2017

Colin D Clyne

6

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Europe PubMed Central

PubMed publication ID

29 July 2017

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publication date

20 December 2010

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Europe PubMed Central

PubMed publication ID

29 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

5

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Europe PubMed Central

PubMed publication ID

29 July 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

e14389

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Creative Commons Attribution 4.0 International

20 December 2010

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April 2022 Public Data File from Crossref

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The ovary: basic biology and clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Detection of nonneutral substitution rates on mammalian phylogenies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Generic binding sites, generic DNA-binding domains: where does specific promoter recognition come from?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Loss of betaglycan contributes to the malignant properties of human granulosa tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Crystal Structures of Multiple GATA Zinc Fingers Bound to DNA Reveal New Insights into DNA Recognition and Self-Association by GATA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Inhibition of proteasome activity sensitizes human granulosa tumor cells to TRAIL-induced cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Potential targets of FOXL2, a transcription factor involved in craniofacial and follicular development, identified by transcriptomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Specific interactions of the wing domains of FOXA1 transcription factor with DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Foxl2 function in ovarian development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Transrepression of estrogen receptor beta signaling by nuclear factor-kappab in ovarian granulosa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Aligning multiple genomic sequences with the threaded blockset aligner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

IRS proteins and the common path to diabetes

1 reference

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4 July 2018

The human genome browser at UCSC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

BLAT—The BLAST-Like Alignment Tool

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Characterization of a novel silencer element in the human aromatase gene PII promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Characterization of an immortalized human granulosa cell line (COV434).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

A CRE-like sequence that binds CREB and contributes to cAMP-dependent regulation of the proximal promoter of the human aromatase P450 (CYP19) gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) gene

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

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4 July 2018

Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila.

1 reference

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4 July 2018

Isolation and expression of a cDNA encoding Renilla reniformis luciferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004790

4 July 2018

Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014389

21 January 2018

Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014389

21 January 2018

Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014389

21 January 2018

Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/steroidogenic factor 1.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014389

21 January 2018

Creating temperature-sensitive winged helix transcription factors. Amino acids that stabilize the DNA binding domain of HNF3.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014389

21 January 2018

Expression status and mutational analysis of the PTEN and P13K subunit genes in ovarian granulosa cell tumors

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014389

21 January 2018

Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014389

21 January 2018

Extinction of FOXL2 expression in aggressive ovarian granulosa cell tumors in children.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014389

21 January 2018

Comparative cytogenetic and molecular studies of DM domain genes in pig and cattle.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014389

21 January 2018

Mutation ofFOXL2in Granulosa-Cell Tumors of the Ovary

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014389

21 January 2018

Mutational analysis of FOXL2 codon 134 in granulosa cell tumour of ovary and other human cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/21188138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative detection of alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in aromatase-expressing human cells by competitive RT-PCR

1 reference

https://pubmed.ncbi.nlm.nih.gov/21188138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Male specific expression suggests role of DMRT1 in human sex determination

1 reference

https://pubmed.ncbi.nlm.nih.gov/21188138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant expression of ovary determining gene FOXL2 in the testis and juvenile granulosa cell tumor in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/21188138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0014389

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

2010PLoSO...514389F

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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