(Q33786789)

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Alzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Alzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

Alzheimer's disease

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object named as

Simon C Drew

1

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Colin L. Masters

2

object named as

Colin L Masters

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Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Kevin J Barnham

3

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Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

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publication date

30 December 2010

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Europe PubMed Central

PubMed publication ID

29 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

e15875

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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Creative Commons Attribution 4.0 International

30 December 2010

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April 2022 Public Data File from Crossref

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Modeling the Cu+ binding in the 1-16 region of the amyloid-β peptide involved in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-beta copper complex follow a preorganization mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Reaction rates and mechanism of the ascorbic acid oxidation by molecular oxygen facilitated by Cu(II)-containing amyloid-beta complexes and aggregates

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4 July 2018

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42.

1 reference

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4 July 2018

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

1 reference

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4 July 2018

Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide

1 reference

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4 July 2018

Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide

1 reference

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4 July 2018

Therapeutics for Alzheimer's disease based on the metal hypothesis

1 reference

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4 July 2018

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

1 reference

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4 July 2018

Metals in Alzheimer's and Parkinson's diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Role of aspartate-1 in Cu(II) binding to the amyloid-beta peptide of Alzheimer's disease

1 reference

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4 July 2018

High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Products of Cu(II)-catalyzed oxidation in the presence of hydrogen peroxide of the 1-10, 1-16 fragments of human and mouse beta-amyloid peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Copper, Zinc, and the Metallobiology of Alzheimer Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Close-range electrostatic interactions in proteins

1 reference

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4 July 2018

Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Cu(2+) Inhibits the Aggregation of Amyloid beta-Peptide(1-42) in vitro We thank JEOL for the AFM measurement. This work was supported in part by Grants-in-Aid from the Japanese Ministry of Education, Science, Sports, and Culture, and a Grant from "R

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Isoaspartate formation and neurodegeneration in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Copper, iron and zinc in Alzheimer's disease senile plaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Purification and characterization of a neuropeptide-degrading aminopeptidase from human brain

1 reference

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4 July 2018

Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

4 July 2018

Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins

1 reference

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Comparison of aminopeptidase, dipeptidyl aminopeptidase and tripeptidyl aminopeptidase activities in brain tissue from normal and Alzheimer's disease cases.

1 reference

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4 July 2018

Copper(II) complex of sulfur-containing peptides. Characterization and similarity of electron spin resonance spectrum to the chromophore in blue copper proteins

1 reference

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4 July 2018

The second Cu(II)-binding site in a proton-rich environment interferes with the aggregation of amyloid-beta(1-40) into amyloid fibrils

1 reference

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21 January 2018

Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-beta peptide--relevance to N-terminally truncated forms.

1 reference

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21 January 2018

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains

1 reference

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21 January 2018

Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

1 reference

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21 January 2018

Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

Isomerization of the Asp7 residue results in zinc-induced oligomerization of Alzheimer's disease amyloid beta(1-16) peptide

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

XSophe-Sophe-XeprView. A computer simulation software suite (v. 1.1.3) for the analysis of continuous wave EPR spectra.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

Structural implications derived from the analysis of electron paramagnetic resonance spectra of natural and artificial copper proteins.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coli.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

Dead time-dependent line distortions in absolute-value electron spin echo envelope modulation spectra.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

N-Terminal deletions modify the Cu2+ binding site in amyloid-beta

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

Copper selectively triggers beta-sheet assembly of an N-terminally truncated amyloid beta-peptide beginning with Glu3.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

Roles of N-terminal pyroglutamate in maintaining structural integrity and pKa values of catalytic histidine residues in bullfrog ribonuclease 3.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

Coordination abilities of the 1-16 and 1-28 fragments of beta-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015875

21 January 2018

Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

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Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta1-42: an AFM study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

30 October 2018

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

30 October 2018

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

30 October 2018

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012727

30 October 2018

N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic post-translationally modified human A beta peptide exhibits a markedly increased tendency to form beta-pleated sheets in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EPR and O2· — scavenger activity: Cu(II)—peptide complexes as superoxide dismutase models

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pulse EPR spectroscopy reveals the coordination sphere of copper(II) ions in the 1-16 amyloid-beta peptide: a key role of the first two N-terminus residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide Hydrolysis in Thermolysin: Ab Initio QM/MM Investigation of the Glu143-Assisted Water Addition Mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective destabilization of soluble amyloid β oligomers by divalent metal ions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyroglutamyl peptidase: an overview of the three known enzymatic forms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209855

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based on heuristic

inferred from PubMed ID database lookup

Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0015875

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

2010PLoSO...515875D

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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