(Q33787274)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

Mauricio Garcia de Souza Costa

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Paulo Ricardo Batista

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Charles H. Robert

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

6

Pedro G Pascutti

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Paulo Mascarello Bisch

5

object named as

Paulo M Bisch

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Cláudio S Shida

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

22 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

11 Suppl 5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

S5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1186/1471-2164-11-s5-s5

19 January 2020

exact match

0 references

cites work

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

1 reference

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Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation

4 July 2018

1 reference

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Computational analysis of the cathepsin B inhibitors activities through LR-MMPBSA binding affinity calculation based on docked complex

4 July 2018

1 reference

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New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics

4 July 2018

1 reference

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Cysteine cathepsin proteases as pharmacological targets in cancer

4 July 2018

1 reference

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Cathepsin cysteine proteases in cardiovascular disease.

4 July 2018

1 reference

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Cysteine cathepsins and the cutting edge of cancer invasion

4 July 2018

1 reference

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Cysteine cathepsins: multifunctional enzymes in cancer

4 July 2018

1 reference

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Inhibitors of cathepsin B.

4 July 2018

1 reference

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Benchmarking pK(a) prediction.

4 July 2018

1 reference

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Very fast empirical prediction and rationalization of protein pKa values

4 July 2018

1 reference

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The influence of amino acid protonation states on molecular dynamics simulations of the bacterial porin OmpF.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Heparan sulfate-protein interactions: therapeutic potential through structure-function insights.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Cysteine cathepsins in human cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Multiple roles for cysteine cathepsins in cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Cell-surface cathepsin B: Understanding its functional significance

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Structural basis of perturbed pKa values of catalytic groups in enzyme active sites

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Electrostatics of nanosystems: application to microtubules and the ribosome

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Collective protein dynamics in relation to function

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Systematic analysis of domain motions in proteins from conformational change: new results on citrate synthase and T4 lysozyme

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

The anticoagulant activation of antithrombin by heparin

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Emerging roles for cysteine proteases in human biology

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

N.m.r. and molecular-modelling studies of the solution conformation of heparin

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Nature of the interaction of heparin with acidic fibroblast growth factor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Tumor cathepsin B and its endogenous inhibitors in metastasis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

pH Dependence of inhibitors targeting the occluding loop of cathepsin B.

4 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-11-S5-S5

Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-11-S5-S5

Electrostatic properties in the catalytic site of papain: A possible regulatory mechanism for the reactivity of the ion pair

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-11-S5-S5

Molecular dynamics simulation of a decasaccharide fragment of heparin in aqueous solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-11-S5-S5

Fluctuation and Cross-correlation Analysis of Protein Motions Observed in Nanosecond Molecular Dynamics Simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-11-S5-S5

Human Cytomegalovirus Protease: Why is the Dimer Required for Catalytic Activity?

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Heparin specifically inhibits binding of V3 loop antibodies to HIV-1 gp120, an effect potentiated by CD4 binding

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045798

Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases

30 October 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2164-11-S5-S5

A classical enzyme active center motif lacks catalytic competence until modulated electrostatically

21 January 2018

1 reference

12 December 2020

Role of the occluding loop in cathepsin B activity

1 reference

12 December 2020

Allosteric formulation of thermal transitions in macromolecules, including effects of ligand binding and oligomerization

1 reference

12 December 2020

Cathepsin B and cysteine protease inhibitors in human osteoarthritis

1 reference

12 December 2020

Cysteine proteinase activity regulation. A possible role of heparin and heparin-like glycosaminoglycans

1 reference

12 December 2020

Human cathepsin B is a metastable enzyme stabilized by specific ionic interactions associated with the active site

1 reference

12 December 2020

Functional significance of flexibility in proteins

1 reference

12 December 2020

10.1186/1471-2164-11-S5-S5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 January 2020

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-2164-11-s5-s5

9 September 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210971%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

21210971

1 reference