(Q33789758)

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Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21220428%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3 (English)

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Europe PubMed Central

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19 January 2020

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19 January 2020

6

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19 January 2020

11

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19 January 2020

Graeme Milligan

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Graeme Milligan

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19 January 2020

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Johannes Schmidt

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19 January 2020

Elisabeth Christiansen

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19 January 2020

Irina G Tikhonova

4

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19 January 2020

Manuel Grundmann

5

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19 January 2020

Richard J Ward

7

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19 January 2020

Christel Drewke

8

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19 January 2020

Evi Kostenis

10

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19 January 2020

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10 January 2011

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19 January 2020

Journal of Biological Chemistry

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19 January 2020

286

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19 January 2020

12

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19 January 2020

10628-10640

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19 January 2020

When simple agonism is not enough: emerging modalities of GPCR ligands.

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Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation

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4 July 2018

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

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4 July 2018

Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3.

1 reference

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7TM pharmacology measured by label-free: a holistic approach to cell signalling

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Cellular assays as portals to seven-transmembrane receptor-based drug discovery

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Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis

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4 July 2018

Transforming fragments into candidates: small becomes big in medicinal chemistry

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The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1

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Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation.

1 reference

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4 July 2018

International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions

1 reference

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4 July 2018

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

1 reference

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4 July 2018

Functional selectivity in GPCR modulator screening

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The evasive nature of drug efficacy: implications for drug discovery

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Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors

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The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target

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Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

1 reference

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Ligand efficiency: a useful metric for lead selection

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Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

1 reference

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4 July 2018

Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

1 reference

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4 July 2018

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

1 reference

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Molecular identification of high and low affinity receptors for nicotinic acid

1 reference

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Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

A holistic view of GPCR signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21220428

12 December 2020

based on heuristic

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Identifiers

10.1074/JBC.M110.210872

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21220428%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PMC publication ID

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Europe PubMed Central

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19 January 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21220428%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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