(Q33793028)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24790081%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Conserved modular domains team up to latch-open active protein kinase Cα (English)

1 reference

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17 March 2020

4

1 reference

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17 March 2020

John Tesmer

6

1 reference

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17 March 2020

Margaret V Westfall

7

1 reference

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17 March 2020

author name string

Carter J Swanson

1

1 reference

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17 March 2020

Michael Ritt

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24790081%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

William Wang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24790081%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Arvind Narayan

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24790081%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Sivaraj Sivaramakrishnan

8

1 reference

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17 March 2020

language of work or name

English

0 references

publication date

30 April 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24790081%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

17 March 2020

published in

1 reference

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17 March 2020

volume

289

1 reference

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17 March 2020

issue

25

1 reference

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17 March 2020

page(s)

17812-17829

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24790081%20AND%20SRC:MED&resulttype=core&format=json

Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α

17 March 2020

cites work

1 reference

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Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells

4 July 2018

1 reference

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Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Visualizing and manipulating focal adhesion kinase regulation in live cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Systematic control of protein interaction using a modular ER/K α-helix linker

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

SMART 7: recent updates to the protein domain annotation resource

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Crystal Structure and Allosteric Activation of Protein Kinase C βII

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Protein kinase Cα as a heart failure therapeutic target

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Activation of protein kinase C isoforms and its impact on diabetic complications

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Structure and function of regulator of G protein signaling homology domains

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

PKC and the control of localized signal dynamics.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

The nuts and bolts of AGC protein kinases

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Combining single-molecule optical trapping and small-angle x-ray scattering measurements to compute the persistence length of a protein ER/K alpha-helix.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Structural basis of protein kinase C isoform function

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Dynamic charge interactions create surprising rigidity in the ER/K alpha-helical protein motif

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

4 July 2018

Expanding mTOR signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Identification of acidic amino acid residues in the protein kinase C alpha V5 domain that contribute to its insensitivity to diacylglycerol

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

The structure of dimeric ROCK I reveals the mechanism for ligand selectivity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cdelta in the intact cell.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

New insights into the structure-function relationships of Rho-associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implications

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Autophosphorylation suppresses whereas kinase inhibition augments the translocation of protein kinase Calpha in response to diacylglycerol

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Measuring the binding of protein kinase C to sucrose-loaded vesicles

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

The catalytic domain limits the translocation of protein kinase C alpha in response to increases in Ca2+ and diacylglycerol

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Regulation of PKC alpha activity by C1-C2 domain interactions

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Initial sequencing and analysis of the human genome

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Insights into nucleotide binding in protein kinase A using fluorescent adenosine derivatives

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Calcium and phosphatidylserine stimulate the self-association of conventional protein kinase C isoforms

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Protein families in multicellular organisms

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Contributions to maxima in protein kinase C activation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Nuclear import of protein kinase C occurs by a mechanism distinct from the mechanism used by proteins with a classical nuclear localization signal

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Formation of membrane domains during the activation of protein kinase C.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Activation of protein kinase C by short chain phosphatidylcholines

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

The mechanism of protein kinase C activation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Autophosphorylation of protein kinase C at three separated regions of its primary sequence

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Fluorescence studies on the interaction of the tumor promoter phorbol myristate acetate and related compounds with rat liver plasma membranes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067214

Inhibition of protein kinase C catalytic activity by additional regions within the human protein kinase Calpha-regulatory domain lying outside of the pseudosubstrate sequence

4 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534750

Regulation of protein kinase C-related protein kinase 2 (PRK2) by an intermolecular PRK2-PRK2 interaction mediated by Its N-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534750

Kinetic mechanism of fully activated S6K1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534750

Scanning mutagenesis studies reveal multiple distinct regions within the human protein kinase C alpha regulatory domain important for phorbol ester-dependent activation of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534750

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534750

Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.534750

Domain structure and phosphorylation of protein kinase C

21 January 2018

1 reference

12 December 2020

Protein kinase C contains a pseudosubstrate prototope in its regulatory domain

1 reference

12 December 2020

Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state

1 reference

12 December 2020

The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Calpha

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M113.534750

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24790081%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24790081%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

24790081

1 reference