(Q33802862)

29 July 2017

title

Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease (English)

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29 July 2017

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Yong Joo Lee

1

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29 July 2017

Shaoxiao Wang

2

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29 July 2017

Sunny R Slone

3

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29 July 2017

Talene A Yacoubian

4

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29 July 2017

Stephan N Witt

5

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29 July 2017

language of work or name

English

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publication date

11 January 2011

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29 July 2017

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29 July 2017

volume

6

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29 July 2017

issue

1

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29 July 2017

page(s)

e15946

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Creative Commons Attribution 4.0 International

29 July 2017

copyright license

start time

11 January 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

4 July 2018

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4 July 2018

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4 July 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

4 July 2018

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4 July 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

4 July 2018

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Sphingolipid functions in Saccharomyces cerevisiae

4 July 2018

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human

4 July 2018

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Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae

4 July 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019226

ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019226

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

4 July 2018

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Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019226

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

4 July 2018

1 reference

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Cloning and characterization of LAG1, a longevity-assurance gene in yeast

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019226

Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019226

Transformation of intact yeast cells treated with alkali cations

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019226

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

4 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

Proteasomal inhibition by alpha-synuclein filaments and oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

Ceramide biosynthesis is required for the formation of the oligomeric H+-ATPase Pma1p in the yeast endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

Functional mitochondria are required for alpha-synuclein toxicity in aging yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

DSPP mutation in dentinogenesis imperfecta Shields type II

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

Antinutritional effects of fumonisin B1 and pathophysiological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015946

Alpha-synuclein and Parkinson's disease

21 January 2018

1 reference

12 December 2020

The chronological life span of Saccharomyces cerevisiae

1 reference

12 December 2020

Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1

1 reference

12 December 2020

1 reference

12 December 2020

Fumonisin B1-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored folate receptor

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0015946

Identifiers

DOI

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29 July 2017

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29 July 2017

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