(Q46765805)

25 December 2017

title

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity (English)

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25 December 2017

main subject

endoplasmic reticulum

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8

Ted M Dawson

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25 December 2017

9

Christopher A Ross

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25 December 2017

author name string

Wanli W Smith

1

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25 December 2017

Haibing Jiang

2

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25 December 2017

Zhong Pei

3

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25 December 2017

Yuji Tanaka

4

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25 December 2017

Hokuto Morita

5

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25 December 2017

Akira Sawa

6

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25 December 2017

Valina L Dawson

7

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25 December 2017

publication date

20 October 2005

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25 December 2017

published in

Human Molecular Genetics

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25 December 2017

volume

14

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25 December 2017

issue

24

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25 December 2017

page(s)

3801-3811

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25 December 2017

Impairment of the ubiquitin-proteasome system by protein aggregation

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Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein

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Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

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Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

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Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

21 January 2018

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21 January 2018

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Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

21 January 2018

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Mitochondrial control of cell death

21 January 2018

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Mitochondrial permeability transition is a central coordinating event of apoptosis

21 January 2018

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Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel.

21 January 2018

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Apoptosis in neural development and disease

21 January 2018

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21 January 2018

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Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

21 January 2018

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

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Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation

21 January 2018

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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

21 January 2018

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Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease

21 January 2018

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Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease?

21 January 2018

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Oxidative Damage to the Endoplasmic Reticulum is Implicated in Ischemic Neuronal Cell Death

21 January 2018

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Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death

21 January 2018

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Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex

21 January 2018

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Protein aggregation and neurodegenerative disease

21 January 2018

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Oxidative stress and inflammation in Parkinson's disease: is there a causal link?

21 January 2018

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Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

21 January 2018

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

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alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro.

21 January 2018

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Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

21 January 2018

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Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome

21 January 2018

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Dopamine induces proteasome inhibition in neural PC12 cell line.

21 January 2018

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Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI396

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

21 January 2018

1 reference

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Perk is essential for translational regulation and cell survival during the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI396

Coupling endoplasmic reticulum stress to the cell death program

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI396

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI396

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI396

Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI396

Induction of neuronal death by α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI396

21 January 2018

Identifiers

DOI

10.1093/HMG/DDI396

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25 December 2017

1 reference

25 December 2017