(Q33811654)

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Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Parkinson's disease

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object named as

Gary W Miller

6

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1

object named as

Stefka Gyoneva

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Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Lauren Shapiro

2

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Europe PubMed Central

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29 July 2017

Carlos Lazo

3

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Europe PubMed Central

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29 July 2017

Ethel Garnier-Amblard

4

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Europe PubMed Central

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29 July 2017

Yoland Smith

5

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Europe PubMed Central

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29 July 2017

Stephen F Traynelis

7

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Europe PubMed Central

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29 July 2017

publication date

13 March 2014

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Europe PubMed Central

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29 July 2017

Neurobiology of Disease

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Europe PubMed Central

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29 July 2017

67

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Europe PubMed Central

PubMed publication ID

29 July 2017

191-202

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Europe PubMed Central

PubMed publication ID

29 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4072497/fullTextXML

based on heuristic

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Dynamic structural remodelling of microglia in health and disease: a review of the models, the signals and the mechanisms

1 reference

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28 July 2018

Microglia: new roles for the synaptic stripper.

1 reference

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28 July 2018

Purinergic receptors in microglia: functional modal shifts of microglia mediated by P2 and P1 receptors

1 reference

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28 July 2018

Microglia and neurodegeneration: the role of systemic inflammation.

1 reference

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28 July 2018

Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity

1 reference

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28 July 2018

Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatum

1 reference

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28 July 2018

Use of ibuprofen and risk of Parkinson disease

1 reference

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28 July 2018

Preladenant in patients with Parkinson's disease and motor fluctuations: a phase 2, double-blind, randomised trial

1 reference

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28 July 2018

Pathophysiological roles for purines: adenosine, caffeine and urate

1 reference

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28 July 2018

Anti-inflammatory drugs and risk of Parkinson disease: A meta-analysis

1 reference

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28 July 2018

Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

1 reference

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28 July 2018

Inactivation of neuronal forebrain A receptors protects dopaminergic neurons in a mouse model of Parkinson's disease

1 reference

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28 July 2018

Adenosine signaling and function in glial cells

1 reference

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28 July 2018

The influence of microglia on the pathogenesis of Parkinson's disease

1 reference

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28 July 2018

Adenosine A(2A) receptor mediates microglial process retraction

1 reference

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28 July 2018

Microglia processes block the spread of damage in the brain and require functional chloride channels

1 reference

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28 July 2018

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.

1 reference

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28 July 2018

Protocol for the MPTP mouse model of Parkinson's disease

1 reference

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28 July 2018

Systemic infections and inflammation affect chronic neurodegeneration

1 reference

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28 July 2018

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

1 reference

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28 July 2018

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

1 reference

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28 July 2018

Targeting adenosine A2A receptors in Parkinson's disease

1 reference

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28 July 2018

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

1 reference

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28 July 2018

Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism

1 reference

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28 July 2018

ATP mediates rapid microglial response to local brain injury in vivo

1 reference

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28 July 2018

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

1 reference

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28 July 2018

The impact of systemic infection on the progression of neurodegenerative disease.

1 reference

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28 July 2018

Microglia as a source and target of cytokines

1 reference

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28 July 2018

Prospective study of caffeine consumption and risk of Parkinson's disease in men and women.

1 reference

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28 July 2018

Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.

1 reference

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28 July 2018

Extracellular metabolism of ATP and other nucleotides

1 reference

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28 July 2018

Association of coffee and caffeine intake with the risk of Parkinson disease

1 reference

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Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

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28 July 2018

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

1 reference

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28 July 2018

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1 reference

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28 July 2018

Microglia: a sensor for pathological events in the CNS

1 reference

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28 July 2018

Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations

1 reference

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28 July 2018

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1 reference

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Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

1 reference

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Dose-dependent destruction of the coeruleus-cortical and nigral-striatal projections by MPTP.

1 reference

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Norepinephrine modulates the motility of resting and activated microglia via different adrenergic receptors

1 reference

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30 October 2018

Preclinical jockeying on the translational track of adenosine A2A receptors

1 reference

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30 October 2018

Effect of caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum.

1 reference

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Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling

1 reference

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30 October 2018

Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys

1 reference

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30 October 2018

Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms.

1 reference

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30 October 2018

Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice.

1 reference

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30 October 2018

Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure.

1 reference

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30 October 2018

Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration

1 reference

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30 October 2018

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30 October 2018

Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

1 reference

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30 October 2018

Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications

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30 October 2018

Nigral degeneration in Parkinson's disease in relation to clinical features

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30 October 2018

The striopallidal neuron: a main locus for adenosine-dopamine interactions in the brain

1 reference

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inferred from PubMed ID database lookup

Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/24632419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease.

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

1 reference

https://pubmed.ncbi.nlm.nih.gov/24632419

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.NBD.2014.03.004

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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