(Q33816616)

29 July 2017

title

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice (English)

1 reference

29 July 2017

Timothy Sullivan

1

1 reference

29 July 2017

Zhenhua Miao

2

1 reference

29 July 2017

Daniel J Dairaghi

3

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29 July 2017

Antoni Krasinski

4

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29 July 2017

Yu Wang

5

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29 July 2017

Bin N Zhao

6

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29 July 2017

Trageen Baumgart

7

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29 July 2017

Linda S Ertl

8

1 reference

29 July 2017

Andrew Pennell

9

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29 July 2017

Lisa Seitz

10

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29 July 2017

Jay Powers

11

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29 July 2017

Ruiping Zhao

12

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29 July 2017

Solomon Ungashe

13

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29 July 2017

Zheng Wei

14

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29 July 2017

Landin Boring

15

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29 July 2017

Chia-Lin Tsou

16

1 reference

29 July 2017

Israel Charo

17

1 reference

29 July 2017

Robert D Berahovich

18

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29 July 2017

Thomas J Schall

19

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29 July 2017

Juan C Jaen

20

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29 July 2017

publication date

28 August 2013

1 reference

American Journal of Physiology - Renal Physiology

29 July 2017

published in

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29 July 2017

volume

305

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29 July 2017

issue

9

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29 July 2017

page(s)

F1288-97

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Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease

29 July 2017

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BTBR Ob/Ob mutant mice model progressive diabetic nephropathy

4 July 2018

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Macrophages, inflammation, and insulin resistance

4 July 2018

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Major contribution of tubular secretion to creatinine clearance in mice.

4 July 2018

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CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis

4 July 2018

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Effect of the monocyte chemoattractant protein-1/CC chemokine receptor 2 system on nephrin expression in streptozotocin-treated mice and human cultured podocytes

4 July 2018

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Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial

4 July 2018

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Proteinuria in diabetic kidney disease: a mechanistic viewpoint

4 July 2018

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4 July 2018

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Obesity-induced inflammation: a metabolic dialogue in the language of inflammation

4 July 2018

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Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

4 July 2018

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Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

4 July 2018

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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

4 July 2018

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The many roles of chemokines and chemokine receptors in inflammation

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle

4 July 2018

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Inflamed fat: what starts the fire?

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

4 July 2018

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Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

Obesity is associated with macrophage accumulation in adipose tissue

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

Obesity-induced inflammatory changes in adipose tissue.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

Monocyte chemoattractant protein 1 in obesity and insulin resistance

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice

4 July 2018

1 reference

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Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy.

4 July 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Pharmacokinetic and pharmacodynamic evaluation of the novel CCR1 antagonist CCX354 in healthy human subjects: implications for selection of clinical dose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Overcoming hurdles in developing successful drugs targeting chemokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Blockade of CCL2/CCR2 signalling ameliorates diabetic nephropathy in db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00316.2013

Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4073927

A novel C-C chemokine receptor 2 antagonist prevents progression of albuminuria and atherosclerosis in mouse models

30 October 2018

1 reference

12 December 2020

Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats

1 reference

12 December 2020

Macrophage accumulation in human progressive diabetic nephropathy

1 reference

12 December 2020

Chemokine receptor antagonists

1 reference

12 December 2020

Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy

1 reference

12 December 2020

The role of macrophages in diabetic glomerulosclerosis

1 reference

12 December 2020

CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE(-/-) mice

1 reference

12 December 2020

Targeting the MCP-1/CCR2 System in diabetic kidney disease

1 reference

12 December 2020

Mouse models of diabetic nephropathy

1 reference

12 December 2020

10.1152/AJPRENAL.00316.2013

Identifiers

DOI

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29 July 2017

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29 July 2017

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