(Q33818943)

29 July 2017

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title

Insights into ligand pharmacology using receptor-G-protein fusion proteins (English)

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29 July 2017

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Milligan G

1

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29 July 2017

publication date

1 January 2000

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Trends in Pharmacological Sciences

29 July 2017

published in

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29 July 2017

volume

21

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29 July 2017

issue

1

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29 July 2017

page(s)

24-28

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Cellular signaling by an agonist-activated receptor/Gs alpha fusion protein

29 July 2017

cites work

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7 January 2021

Restricting mobility of Gsalpha relative to the beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity

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7 January 2021

Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-gsalpha fusion protein

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7 January 2021

Activation of the beta(2)-adrenergic receptor-Galpha(s) complex leads to rapid depalmitoylation and inhibition of repalmitoylation of both the receptor and Galpha(s).

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7 January 2021

Measurement of agonist-induced guanine nucleotide turnover by the G-protein Gi1alpha when constrained within an alpha2A-adrenoceptor-Gi1alpha fusion protein

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7 January 2021

Rescue of functional interactions between the alpha2A-adrenoreceptor and acylation-resistant forms of Gi1alpha by expressing the proteins from chimeric open reading frames.

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7 January 2021

Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-

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7 January 2021

Quantitative analysis of a cysteine351glycine mutation in the G protein Gi1alpha: effect on alpha2A-adrenoceptor-Gi1alpha fusion protein activation

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7 January 2021

Measurement of agonist efficacy using an alpha2A-adrenoceptor-Gi1alpha fusion protein

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7 January 2021

Comparative analysis of the efficacy of A1 adenosine receptor activation of Gi/o alpha G proteins following coexpression of receptor and G protein and expression of A1 adenosine receptor-Gi/o alpha fusion proteins

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Efficient signal transduction by a chimeric yeast-mammalian G protein alpha subunit Gpa1-Gsalpha covalently fused to the yeast receptor Ste2.

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Analysis of agonist function at fusion proteins between the IP prostanoid receptor and cognate, unnatural and chimaeric G-proteins

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Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein

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7 January 2021

Modulation of relative intrinsic activity of agonists at the alpha-2A adrenoceptor by mutation of residue 351 of G protein gi1alpha

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7 January 2021

Kinetics of ternary complex formation with fusion proteins composed of the A(1)-adenosine receptor and G protein alpha-subunits.

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7 January 2021

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

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7 January 2021

Agonist and inverse agonist efficacy at human recombinant serotonin 5-HT1A receptors as a function of receptor:G-protein stoichiometry

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Selective activation of a chimeric Gi1/Gs G protein alpha subunit by the human IP prostanoid receptor: analysis using agonist stimulation of high affinity GTPase activity and [35S]guanosine-5'-O-(3-thio)triphosphate binding.

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How receptors talk to trimeric G proteins

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7 January 2021

Chimaeric G alpha proteins: their potential use in drug discovery

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7 January 2021

Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding

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7 January 2021

Hydrophobicity of residue351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor.

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7 January 2021

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation

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7 January 2021

Efficacy of inverse agonists in cells overexpressing a constitutively active beta2-adrenoceptor and type II adenylyl cyclase

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Agonist-independent activation of Gz by the 5-hydroxytryptamine1A receptor co-expressed in Spodoptera frugiperda cells. Distinguishing inverse agonists from neutral antagonists

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Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635

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7 January 2021

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7 January 2021

Emerging roles for RGS proteins in cell signalling

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7 January 2021

10.1016/S0165-6147(99)01404-2

Identifiers

DOI

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29 July 2017

1 reference