(Q33818953)

29 July 2017

NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation (English)

1 reference

29 July 2017

E E Bosco

1

1 reference

29 July 2017

Y Nakai

2

1 reference

29 July 2017

R F Hennigan

3

1 reference

29 July 2017

N Ratner

4

1 reference

29 July 2017

Y Zheng

5

1 reference

29 July 2017

language of work or name

English

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publication date

15 February 2010

1 reference

29 July 2017

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29 July 2017

29

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29 July 2017

17

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29 July 2017

2540-2549

1 reference

https://scigraph.springernature.com/pub.10.1038/onc.2010.20

29 July 2017

0 references

cites work

Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Merlin is a potent inhibitor of glioma growth

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Crystal structure of a beta-catenin/BCL9/Tcf4 complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Role of Rho-family proteins in cell adhesion and cancer.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

4 July 2018

RHO-GTPases and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

p21-activated kinase links Rac/Cdc42 signaling to merlin

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861729

Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology

4 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.20

Rho GTPases are over-expressed in human tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.20

Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.20

Wnt signaling controls the phosphorylation status of beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.20

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.20

Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.20

Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.20

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.20

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference