(Q33836807)

29 July 2017

title

Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). (English)

1 reference

29 July 2017

36

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22

Antonia Trichopoulou

0 references

Bas Bueno-de-Mesquita

29

H Bas Bueno-de-Mesquita

1 reference

29 July 2017

7

Anne Tjønneland

1 reference

29 July 2017

5

Heiner Boeing

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29 July 2017

16

Aurelio Barricarte

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Nerea Larrañaga

14

Nerea Larrañaga

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Sabina Sieri

Sabina Sieri

25

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Federico Canzian

Federico Canzian

37

0 references

Tobias Pischon

Tobias Pischon

6

0 references

José María Huerta

José María Huerta

15

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Carlotta Sacerdote

Carlotta Sacerdote

27

0 references

Domenico Palli

Domenico Palli

24

0 references

Mattias Johansson

Mattias Johansson

31

0 references

Kay-Tee Khaw

17

Kay-Tee Khaw

1 reference

29 July 2017

38

Rudolf Kaaks

1 reference

29 July 2017

26

Rosario Tumino

1 reference

29 July 2017

9

Kim Overvad

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29 July 2017

Afshan Siddiq

35

0 references

Dimitris Trichopoulos

23

Dimitrios Trichopoulos

1 reference

29 July 2017

30

Göran Hallmans

1 reference

29 July 2017

18

Nicholas Wareham

1 reference

29 July 2017

34

David G Cox

1 reference

29 July 2017

21

Pagona Lagiou

1 reference

29 July 2017

33

Mazda Jenab

1 reference

29 July 2017

19

Ruth C Travis

1 reference

29 July 2017

32

Isabelle Romieu

1 reference

29 July 2017

Daniele Campa

1

1 reference

29 July 2017

Anika Hüsing

2

1 reference

29 July 2017

Angelika Stein

3

1 reference

29 July 2017

Lucie Dostal

4

1 reference

29 July 2017

Nina Roswall

8

1 reference

29 July 2017

Jane Nautrup Østergaard

10

1 reference

29 July 2017

Laudina Rodríguez

11

1 reference

29 July 2017

Núria Sala

12

1 reference

29 July 2017

Maria-José Sánchez

13

1 reference

29 July 2017

Naomi E Allen

20

1 reference

29 July 2017

Henk van Kranen

28

1 reference

29 July 2017

language of work or name

English

0 references

publication date

23 February 2011

1 reference

29 July 2017

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29 July 2017

volume

6

1 reference

29 July 2017

issue

2

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29 July 2017

page(s)

e16914

1 reference

Creative Commons Attribution 4.0 International

29 July 2017

copyright license

start time

23 February 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Opposite roles of MRF4 and MyoD in cell proliferation and myogenic differentiation.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Cell signaling and function organized by PB1 domain interactions.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Targeting mTOR for cancer treatment.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Efficiency and power in genetic association studies

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Current status of mammalian target of rapamycin inhibitors in lung cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

MatInspector and beyond: promoter analysis based on transcription factor binding sites

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

mTOR: A Mediator of Intracellular Homeostasis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Integration of growth factor and nutrient signaling: implications for cancer biology

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Genetic alterations in prostate cancer cell lines detected by comparative genomic hybridization

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

Integration of Growth Factor and Nutrient Signaling

4 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016914

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016914

Atypical protein kinase Clambda binds and regulates p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016914

Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016914

Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016914

Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016914

A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016914

mTOR as a target for therapy of renal cancer.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044148

The overexpression and altered localization of the atypical protein kinase C λ/ι in breast cancer correlates with the pathologic type of these tumors

29 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016914

Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21373201

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Prostate cancer: beta control your hormones

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21373201

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21373201

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0016914

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference