(Q33836952)

English

Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

4 references

17 September 2019

2 October 2019

11 November 2019

17 December 2020

Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

heterocyclic compound

1 reference

17 September 2019

mechanism of action

1 reference

2 October 2019

1 reference

11 November 2019

1 reference

ChEBI release 2020-05-28

1 reference

17 December 2020

author name string

Barbara C Potts

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Kin S Lam

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

25 March 2010

5 references

Europe PubMed Central

PubMed publication ID

29 July 2017

17 September 2019

2 October 2019

11 November 2019

17 December 2020

5 references

Europe PubMed Central

PubMed publication ID

29 July 2017

17 September 2019

2 October 2019

11 November 2019

17 December 2020

8

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

835-880

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

copyright license

Creative Commons Attribution 3.0 Unported

4 references

Europe PubMed Central

17 September 2019

Europe PubMed Central

2 October 2019

Europe PubMed Central

11 November 2019

Europe PubMed Central

17 December 2020

copyright status

0 references

Formal synthesis of salinosporamide A via NHC-catalyzed intramolecular lactonization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

The role of ubiquitin in NF-kappaB regulatory pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Advances in and applications of proteasome inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Marine actinomycetes: a new source of compounds against the human malaria parasite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Biosynthesis of glycopeptides: prospects for improved antibacterials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Proteasome inhibitors in cancer therapy: lessons from the first decade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Discovery and characterization of a marine bacterial SAM-dependent chlorinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Enantioselective total synthesis of (-)-Salinosporamide A (NPI-0052).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Total synthesis of lactacystin and salinosporamide A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

20S proteasome and its inhibitors: crystallographic knowledge for drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

A novel proteasome inhibitor NPI-0052 as an anticancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Total synthesis of natural tert-alkylamino hydroxy carboxylic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Total synthesis of salinosporamide A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Production of novel rapamycin analogs by precursor-directed biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

A simple stereocontrolled synthesis of salinosporamide A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

A phase 2 study of bortezomib in relapsed, refractory myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

The ubiquitin system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Lactacystin, proteasome function, and cell fate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Structure of 20S proteasome from yeast at 2.4 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Biological variation of microbial metabolites by precursor-directed biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Mutational biosynthesis of a new antibiotic, streptomutin A, by an idiotroph of Streptomyces griseus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Biosynthesis of aminocyclitol antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866466

4 July 2018

Approval summary for bortezomib for injection in the treatment of multiple myeloma

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Early clinical experience with the novel proteasome inhibitor PS-519.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Entry to heterocycles based on indium-catalyzed conia-ene reactions: asymmetric synthesis of (-)-salinosporamide A.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Antiprotealide is a natural product.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Defined salt formulations for the growth of Salinispora tropica strain NPS21184 and the production of salinosporamide A (NPI-0052) and related analogs

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Effect of cobalt and vitamin B12 on the production of salinosporamides by Salinispora tropica

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Characterization of product capture resin during microbial cultivations.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

A mechanistic and kinetic study of the beta-lactone hydrolysis of Salinosporamide A (NPI-0052), a novel proteasome inhibitor.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Stabilization Effect of Resin on the Production of Potent Proteasome Inhibitor NPI-0052 During Submerged Fermentation of Salinispora tropica

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

New pacidamycin antibiotics through precursor-directed biosynthesis

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues.

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Branched-chain amino acid catabolism provides precursors for the Type II polyketide antibiotic, actinorhodin, via pathways that are nutrient dependent

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Generation of novel pikromycin antibiotic products through mutasynthesis

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

A concise and straightforward total synthesis of (+/-)-salinosporamide A, based on a biosynthesis model

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Diastereoselective syntheses of deoxydysibetaine, dysibetaine, and its 4-epimer

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Diastereoselective nickel-catalyzed reductive aldol cyclizations using diethylzinc as the stoichiometric reductant: scope and mechanistic insight

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

Cinnabaramides A−G: Analogues of Lactacystin and Salinosporamide from a Terrestrial Streptomycete

1 reference

https://api.crossref.org/works/10.3390%2FMD8040835

21 January 2018

The effect of cerulenin on the production of esperamicin A1 by Actinomadura verrucosospora

1 reference

https://pubmed.ncbi.nlm.nih.gov/20479958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20479958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bicyclic- and tricyclic-beta-lactones via organonucleophile-promoted bis-cyclizations of keto acids: Enantioselective synthesis of (+)-dihydroplakevulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20479958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20479958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20479958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted therapy in acute myeloid leukaemia: current status and future directions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20479958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New synthetic route for the enantioselective total synthesis of salinosporamide A and biologically active analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/20479958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total synthesis and biological activity of lactacystin, omuralide and analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20479958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A concise total synthesis of salinosporamide A

1 reference

https://pubmed.ncbi.nlm.nih.gov/20479958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total synthesis of salinosporamide A

1 reference

https://pubmed.ncbi.nlm.nih.gov/20479958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/MD8040835

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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