(Q33843725)

29 July 2017

title

Driven to death: Inhibition of farnesylation increases Ras activity and promotes growth arrest and cell death [corrected] (English)

1 reference

29 July 2017

1 reference

Mandy Geryk-Hall

1

1 reference

29 July 2017

Yanwen Yang

series ordinal

2

1 reference

29 July 2017

Dennis P M Hughes

series ordinal

3

1 reference

29 July 2017

publication date

20 April 2010

1 reference

Molecular Cancer Therapeutics

29 July 2017

published in

1 reference

29 July 2017

volume

9

1 reference

29 July 2017

issue

5

1 reference

29 July 2017

page(s)

1111-1119

1 reference

Metastatic osteosarcoma gene expression differs in vitro and in vivo

29 July 2017

cites work

1 reference

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Critical role of notch signaling in osteosarcoma invasion and metastasis

5 July 2018

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A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia

5 July 2018

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5 July 2018

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R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation

5 July 2018

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Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

5 July 2018

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Nonconventional trafficking of Ras associated with Ras signal organization

5 July 2018

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HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway

5 July 2018

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PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

5 July 2018

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Lipid posttranslational modifications. Farnesyl transferase inhibitors

5 July 2018

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Recent advances in understanding the antineoplastic mechanisms of farnesyltransferase inhibitors

5 July 2018

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Prenylation is not necessary for endogenous Ras activation in non-malignant cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Refinement and prediction of protein prenylation motifs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Bisphosphonate treatment of bone disease

5 July 2018

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Unraveling the mechanism of the farnesyltransferase enzyme

5 July 2018

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Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia

5 July 2018

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ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

5 July 2018

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Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity

5 July 2018

1 reference

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K-Ras and H-Ras activation promote distinct consequences on endometrial cell survival

5 July 2018

1 reference

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Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations

5 July 2018

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Farnesyltransferase inhibitors in hematologic malignancies: new horizons in therapy

5 July 2018

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RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor

5 July 2018

1 reference

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Insider information: how palmitoylation of Ras makes it a signaling double agent

5 July 2018

1 reference

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Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness.

5 July 2018

1 reference

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Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Blocking oncogenic Ras signaling for cancer therapy

5 July 2018

1 reference

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Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

5 July 2018

1 reference

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Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation.

5 July 2018

1 reference

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Characterization of HDJ-2, a human 40 kD heat shock protein

5 July 2018

1 reference

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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

5 July 2018

1 reference

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Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Mutational activation of ras genes is absent in pediatric osteosarcoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Biochemistry of protein prenylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Cellular senescence induced by p53-ras cooperation is independent of p21waf1 in murine embryo fibroblasts

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Immunocytochemical assay for Ras activity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868119

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20406948

12 December 2020

inferred from PubMed ID database lookup

Post-prenylation-processing enzymes as new targets in oncogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20406948

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/1535-7163.MCT-09-0833

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/o4mlsuqwsreqrm2qikzndf5rpi

30 July 2022

release_o4mlsuqwsreqrm2qikzndf5rpi

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/o4mlsuqwsreqrm2qikzndf5rpi

30 July 2022

https://api.fatcat.wiki/v0/release/o4mlsuqwsreqrm2qikzndf5rpi

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30 July 2022

https://api.fatcat.wiki/v0/release/o4mlsuqwsreqrm2qikzndf5rpi

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30 July 2022