(Q33855150)

29 July 2017

title

Prodrug activation by Cryptosporidium thymidine kinase (English)

1 reference

29 July 2017

Boris Striepen

9

0 references

Pradipsinh K. Rathod

7

object named as

Pradipsinh K Rathod

1 reference

29 July 2017

Xin E Sun

1

1 reference

29 July 2017

Lisa Sharling

2

1 reference

29 July 2017

Mani Muthalagi

3

1 reference

29 July 2017

Devaraja G Mudeppa

4

1 reference

29 July 2017

Krzysztof W Pankiewicz

5

1 reference

29 July 2017

Krzysztof Felczak

6

1 reference

29 July 2017

Jan Mead

8

1 reference

29 July 2017

Lizbeth Hedstrom

10

1 reference

29 July 2017

language of work or name

English

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publication date

15 March 2010

1 reference

Journal of Biological Chemistry

29 July 2017

published in

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29 July 2017

volume

285

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29 July 2017

issue

21

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29 July 2017

page(s)

15916-15922

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The role of ATP-binding cassette (ABC) proteins in protozoan parasites

29 July 2017

cites work

1 reference

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Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen

28 July 2018

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Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future.

28 July 2018

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Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis

28 July 2018

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Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

Modulation of gene expression of three Cryptosporidium parvum ATP-binding cassette transporters in response to drug treatment

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies

28 July 2018

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Functional characterization of a gene encoding a dual domain for uridine kinase and uracil phosphoribosyltransferase in Arabidopsis thaliana

28 July 2018

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An updated review on Cryptosporidium and Giardia

28 July 2018

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Application of quantitative real-time reverse transcription-PCR in assessing drug efficacy against the intracellular pathogen Cryptosporidium parvum in vitro

28 July 2018

1 reference

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The genome of the protist parasite Entamoeba histolytica

28 July 2018

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Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

Gene transfer in the evolution of parasite nucleotide biosynthesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

Biology, persistence and detection of Cryptosporidium parvum and Cryptosporidium hominis oocyst

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity

28 July 2018

1 reference

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Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity

28 July 2018

1 reference

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Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

Efficacy of select antivirals against Cryptosporidium parvum in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

3'-Amino thymidine affinity matrix for the purification of herpes simplex virus thymidine kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

Reversible ATP-dependent transition between two forms of human cytosolic thymidine kinase with different enzymatic properties

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

The infectivity of Cryptosporidium parvum in healthy volunteers

28 July 2018

1 reference

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Human thymidine kinase 1. Regulation in normal and malignant cells

28 July 2018

1 reference

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Mammalian deoxyribonucleoside kinases

28 July 2018

1 reference

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Mechanism of regulation of deoxythymidine kinase of Escherichia coli. I. Effect of regulatory deoxynucleotides on the state of aggregation of the enzyme.

28 July 2018

1 reference

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Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: relevance to cell growth inhibition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

45 Thymidine kinase from Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

Cryptosporidiosis and the challenges of chemotherapy

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

The role of thymidine kinases in the activation of pyrimidine nucleoside analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

21 January 2018

Fluorinated nucleosides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

A spectrophotometric assay for quantitative determination of kcat of herpes simplex virus type 1 thymidine kinase substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

Mucosal cytokine and antigen-specific responses to Cryptosporidium parvum in IL-12p40 KO mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

Adenosine kinase from Cryptosporidium parvum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

High-level expression and purification of human thymidine kinase 1: quaternary structure, stability, and kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

Mechanism-based inhibition of thymidylate synthase by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

Kinetic characterization of bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium hominis: a paradigm shift for ts activity and channeling behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.101543

Potentiation of the antitumor activity of alpha, alpha, alpha-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNA.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

A new method for evaluating experimental cryptosporidial parasite loads using immunofluorescent flow cytometry.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871459

Improved purification methods for calf-derived Cryptosporidium parvum oocysts using discontinuous sucrose and cesium chloride gradients

29 October 2018

1 reference

12 December 2020

Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2'-deoxyribonucleosides

1 reference

12 December 2020

Susceptibility to Cryptosporidium parvum infections in cytokine- and chemokine-receptor knockout mice

1 reference

12 December 2020

A rapid assay for nucleotide kinases using C14-or H3-labeled nucleotides

1 reference

12 December 2020

DEOXYTHYMIDINE KINASE OF ESCHERICHIA COLI. II. KINETICS AND FEEDBACK CONTROL

1 reference

12 December 2020

Purification and characterization of wild-type and mutant TK1 type kinases from Caenorhabditis elegans

1 reference

12 December 2020

Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase

1 reference

12 December 2020

Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis

1 reference

12 December 2020

Cellular sources of thymidine nucleotides: studies for PET

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.101543

1 reference

29 July 2017

1 reference

29 July 2017

1 reference