(Q44765738)

English

Kinetic characterization of bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium hominis: a paradigm shift for ts activity and channeling behavior

scientific article published on 12 February 2004

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Kinetic characterization of bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium hominis: a paradigm shift for ts activity and channeling behavior (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

1 reference

based on heuristic

inferred from title

Cryptosporidium hominis

1 reference

based on heuristic

inferred from title

author name string

Chloé E Atreya

1

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Karen S Anderson

2

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

language of work or name

0 references

publication date

12 February 2004

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

number of pages

9

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

279

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

18314-18322

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Insights into antifolate resistance from malarial DHFR-TS structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase. Evidence for a TS intermediate and TS half-sites reactivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

An electrostatic highway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Toxoplasmic encephalitis in AIDS.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Cryptosporidiosis: laboratory investigations and chemotherapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Cryptosporidiosis: an emerging, highly infectious threat

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Human cryptosporidiosis in immunocompetent and immunodeficient persons. Studies of an outbreak and experimental transmission

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Heterologous expression of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania major

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Thymidylate synthase as a translational regulator of cellular gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Divergent regulation of dihydrofolate reductase between malaria parasite and human host

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Crystalline Dihydropteroylglutamic Acid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Substrate channeling and domain-domain interactions in bifunctional thymidylate synthase-dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400009200

21 January 2018

Identifiers

10.1074/JBC.M400009200

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

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