(Q44294296)

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Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554089%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554089%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Plasmodium falciparum

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Yongyuth Yuthavong

5

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17 December 2019

Sumalee Kamchonwongpaisan

4

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Sumalee Kamchonwongpaisan

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17 December 2019

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Jantanee Wattanarangsan

1

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17 December 2019

Sudsanguan Chusacultanachai

2

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17 December 2019

Jirundon Yuvaniyama

3

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17 December 2019

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1 January 2003

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17 December 2019

Molecular and Biochemical Parasitology

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17 December 2019

126

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17 December 2019

1

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17 December 2019

97-102

1 reference

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PubMed publication ID

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17 December 2019

An overview of chemotherapeutic targets for antimalarial drug discovery

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Antimalarial drug development and new targets

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Thymidylate synthase-dihydrofolate reductase in protozoa

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Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum

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Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance

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Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria

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Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria

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Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

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Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain.

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Basis for antifolate action and resistance in malaria.

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Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

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Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii.

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Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

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7 January 2021

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Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains

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7 January 2021

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Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

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Functional expression of the dihydrofolate reductase and thymidylate synthetase activities of the human malaria parasite Plasmodium falciparum in Escherichia coli

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7 January 2021

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Novel antifolate resistant mutations of Plasmodium falciparum dihydrofolate reductase selected in Escherichia coli

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Complete replacement set of amino acids at the C-terminus of thymidylate synthase: quantitative structure-activity relationship of mutants of an enzyme

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Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum

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7 January 2021

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Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance

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7 January 2021

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Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy resistance

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Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building

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The dihydrofolate reductase domain of rodent malarias: point mutations and pyrimethamine resistance

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7 January 2021

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Analysis of the Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene sequence.

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Antifolate drug selection results in duplication and rearrangement of chromosome 7 in Plasmodium chabaudi

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Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major

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X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex

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Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

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Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin

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Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcanii

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Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs

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The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution

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The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability

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RASMOL: biomolecular graphics for all

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Identifiers

10.1016/S0166-6851(02)00240-2

1 reference

Europe PubMed Central

PubMed publication ID

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17 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12554089%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

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