(Q73958351)

English

Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance

scientific article published on 01 May 2000

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scholarly article

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8 November 2019

Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance (English)

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8 November 2019

Plasmodium falciparum

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inferred from title

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Giulio Rastelli

1

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8 November 2019

Yongyuth Yuthavong

9

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8 November 2019

author name string

W Sirawaraporn

2

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8 November 2019

P Sompornpisut

3

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8 November 2019

T Vilaivan

4

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8 November 2019

S Kamchonwongpaisan

5

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8 November 2019

R Quarrell

6

1 reference

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8 November 2019

G Lowe

7

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8 November 2019

Y Thebtaranonth

8

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8 November 2019

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publication date

1 May 2000

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8 November 2019

Bioorganic & Medicinal Chemistry

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8 November 2019

8

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8 November 2019

5

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8 November 2019

1117-1128

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8 November 2019

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine

1 reference

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7 January 2021

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Plasmodium falciparum: molecular characterization of multidrug-resistant Cambodian isolates

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Point mutations and pyrimethamine resistance in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Pyrimethamine resistant mutations in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Plasmodium falciparum: kinetic interactions of WR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Advances in comparative protein-structure modelling

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Lead discovery of inhibitors of the dihydrofolate reductase domain of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of human dihydrofolate reductase complexed with folate

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Basic local alignment search tool

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of simple potential functions for simulating liquid water

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Protonated state of methotrexate, trimethoprim, and pyrimethamine bound to dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Carbon-13 nuclear magnetic resonance study of protonation of methotrexate and aminopterin bound to dihydrofolate reductase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleotide sequence of the E. coli gene coding for dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Primary structure of chicken liver dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2900022-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation and expression of the Pneumocystis carinii dihydrofolate reductase gene

1 reference

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7 January 2021

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inferred from DOI database lookup

Identifiers

10.1016/S0968-0896(00)00022-5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882022%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882022%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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