(Q43906584)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880049%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

title

Basis for antifolate action and resistance in malaria (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880049%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

0 references

1

1 reference

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7 December 2019

author name string

Yongyuth Yuthavong

series ordinal

1

1 reference

27 November 2017

publication date

1 February 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880049%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

published in

Microbes and Infection

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880049%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880049%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880049%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

page(s)

175-182

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880049%20AND%20SRC:MED&resulttype=core&format=json

Thymidylate synthase-dihydrofolate reductase in protozoa

7 December 2019

cites work

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7 January 2021

An overview of chemotherapeutic targets for antimalarial drug discovery

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7 January 2021

Kinetic and molecular properties of dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi

1 reference

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7 January 2021

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum

1 reference

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7 January 2021

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria

1 reference

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7 January 2021

The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites

1 reference

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7 January 2021

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance

1 reference

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7 January 2021

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria

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7 January 2021

Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine

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7 January 2021

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

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7 January 2021

Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant

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7 January 2021

Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance

1 reference

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7 January 2021

Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast

1 reference

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7 January 2021

Pyrimethamine resistant mutations in Plasmodium falciparum

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7 January 2021

Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.

1 reference

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7 January 2021

A biochemical and genetic model for parasite resistance to antifolates. Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in Plasmodium falciparum.

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7 January 2021

Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

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7 January 2021

Lead discovery of inhibitors of the dihydrofolate reductase domain of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase

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7 January 2021

Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building

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7 January 2021

Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance

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7 January 2021

Chemotherapy for falciparum malaria: the armoury, the problems and the prospects

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7 January 2021

Treatment of Plasmodium falciparum malaria with pyrimethamine-sulfadoxine: selective pressure for resistance is a function of long elimination half-life

1 reference

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7 January 2021

Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum

1 reference

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7 January 2021

The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901525-8

7 January 2021

Synergism in the folate pathway

1 reference

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7 January 2021

Antagonism of sulfadoxine and pyrimethamine antimalarial activity in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acid

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7 January 2021

In vitro activities of and mechanisms of resistance to antifol antimalarial drugs

1 reference

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7 January 2021

De novo and salvage biosynthesis of pteroylpentaglutamates in the human malaria parasite, Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901525-8

7 January 2021

Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901525-8

7 January 2021

On ;the efficacy of antifolate antimalarial combinations in Africa'

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901525-8

7 January 2021

Selection and synergy in Plasmodium falciparum

1 reference

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7 January 2021

Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergy

1 reference

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7 January 2021

Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901525-8

7 January 2021

Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum

1 reference

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7 January 2021

Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins

1 reference

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7 January 2021

Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum

1 reference

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7 January 2021

More on 'the efficacy of antifolate antimalarial combinations in Africa'.

1 reference

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7 January 2021

Molecular basis of in vivo resistance to sulfadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites.

1 reference

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7 January 2021

Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901525-8

7 January 2021

Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901525-8

7 January 2021

Pyrimethamine-sulfadoxine efficacy and selection for mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase in Mali

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901525-8

7 January 2021

Antibacterial synergism: a proposal for chemotherapeutic potentiation between trimethoprim and sulfamethoxazole

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901525-8

7 January 2021

Potentiating effect of pyrimethamine and sulfadoxine against dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901525-8

7 January 2021

10.1016/S1286-4579(01)01525-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880049%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference