(Q33856038)

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Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5 (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Amy Hauck Newman

5

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Amy Hauck Newman

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

P. Jeffrey Conn

4

object named as

P Jeffrey Conn

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Peng Zhang

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Mu-Fa Zou

2

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29 July 2017

Alice L Rodriguez

3

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Europe PubMed Central

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29 July 2017

language of work or name

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publication date

27 March 2010

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Europe PubMed Central

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29 July 2017

Bioorganic & Medicinal Chemistry

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Europe PubMed Central

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29 July 2017

18

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Europe PubMed Central

PubMed publication ID

29 July 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

3026-3035

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Recent progress in the discovery and development of negative allosteric modulators of mGluR5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

The ups and downs of addiction: role of metabotropic glutamate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

5 July 2018

Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

29 October 2018

Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

29 October 2018

Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

29 October 2018

Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

29 October 2018

Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871681

29 October 2018

Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/20382541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20382541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/20382541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

1 reference

https://pubmed.ncbi.nlm.nih.gov/20382541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20382541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20382541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMC.2010.03.053

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

release_ry7si77avfgxdnpz2e7q2duusq

1 reference

https://api.fatcat.wiki/v0/release/ry7si77avfgxdnpz2e7q2duusq

24 November 2022

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mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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