(Q33857580)

29 July 2017

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title

The Smads: transcriptional regulation and mouse models (English)

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29 July 2017

Datto M

1

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29 July 2017

Wang XF

series ordinal

2

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29 July 2017

publication date

1 March 2000

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Cytokine and Growth Factor Reviews

29 July 2017

published in

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29 July 2017

volume

11

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29 July 2017

issue

1-2

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29 July 2017

page(s)

37-48

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Regulation of immune responses by TGF-beta

29 July 2017

cites work

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Regulation of differentiation by TGF-beta

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7 January 2021

Molecular mechanisms of transforming growth factor-beta signaling

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7 January 2021

TGF-beta signal transduction

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7 January 2021

TGF-beta receptors and actions

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7 January 2021

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components

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7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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7 January 2021

Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1

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7 January 2021

A human Mad protein acting as a BMP-regulated transcriptional activator

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7 January 2021

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth

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7 January 2021

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

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7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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7 January 2021

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

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7 January 2021

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

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7 January 2021

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

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7 January 2021

From receptor to nucleus: the Smad pathway

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7 January 2021

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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7 January 2021

Regulation of Smad signalling by protein associations and signalling crosstalk

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7 January 2021

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.

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7 January 2021

Smad6 inhibits signalling by the TGF-beta superfamily

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7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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7 January 2021

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

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7 January 2021

Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins

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7 January 2021

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

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7 January 2021

Human Smad3 and Smad4 are sequence-specific transcription activators

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7 January 2021

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

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7 January 2021

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm

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7 January 2021

Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction

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7 January 2021

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

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7 January 2021

Smad4/DPC4 and Smad3 mediate transforming growth factor-beta (TGF-beta) signaling through direct binding to a novel TGF-beta-responsive element in the human plasminogen activator inhibitor-1 promoter

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7 January 2021

Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation

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7 January 2021

Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene

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7 January 2021

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

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7 January 2021

Smad-dependent transcriptional activation of human type VII collagen gene (COL7A1) promoter by transforming growth factor-beta

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7 January 2021

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

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7 January 2021

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer

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7 January 2021

A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3

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7 January 2021

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

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7 January 2021

A transcriptional partner for MAD proteins in TGF-beta signalling

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7 January 2021

Smad4 and FAST-1 in the assembly of activin-responsive factor

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7 January 2021

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

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7 January 2021

FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals

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7 January 2021

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

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7 January 2021

Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding

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7 January 2021

Characterization of human FAST-1, a TGF beta and activin signal transducer

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7 January 2021

Smads bind directly to the Jun family of AP-1 transcription factors

1 reference

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7 January 2021

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

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7 January 2021

Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators

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https://api.crossref.org/works/10.1016%2FS1359-6101%2899%2900027-1

7 January 2021

Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3

1 reference

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7 January 2021

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

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7 January 2021

The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

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7 January 2021

SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes

1 reference

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7 January 2021

1 alpha,25-Dihydroxyvitamin D3 increases transforming growth factor and transforming growth factor receptor type I and II synthesis in human bone cells

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7 January 2021

Regulation of osteogenic differentiation of human bone marrow stromal cells: interaction between transforming growth factor-beta and 1,25(OH)(2) vitamin D(3) In vitro

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7 January 2021

Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements

1 reference

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7 January 2021

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

1 reference

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7 January 2021

Role of p300, a transcriptional coactivator, in signalling of TGF-beta

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7 January 2021

TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein

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7 January 2021

Physical and functional interaction of SMADs and p300/CBP

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7 January 2021

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

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7 January 2021

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

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7 January 2021

Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling

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7 January 2021

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

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7 January 2021

A Smad transcriptional corepressor

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7 January 2021

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

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7 January 2021

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

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7 January 2021

Smad3 mutant mice develop metastatic colorectal cancer

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7 January 2021

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

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7 January 2021

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.

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7 January 2021

Smad2 role in mesoderm formation, left-right patterning and craniofacial development

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7 January 2021

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

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7 January 2021

Biology of TGF-beta in knockout and transgenic mouse models

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7 January 2021

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

1 reference

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7 January 2021

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

1 reference

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7 January 2021

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

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7 January 2021

Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

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7 January 2021

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

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7 January 2021

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

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https://api.crossref.org/works/10.1016%2FS1359-6101%2899%2900027-1

7 January 2021

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells

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7 January 2021

Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells

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7 January 2021

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

1 reference

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7 January 2021

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

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7 January 2021

Inflammation and TGF beta 1: lessons from the TGF beta 1 null mouse

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7 January 2021

Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia

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7 January 2021

Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning

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7 January 2021

In vivo stimulation of bone formation by transforming growth factor-beta

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7 January 2021

In vivo effects of human recombinant transforming growth factor beta on bone turnover in normal mice

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7 January 2021

Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.

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7 January 2021

Chemotactic response of osteoblastlike cells to transforming growth factor beta

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7 January 2021

Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2899%2900027-1

7 January 2021

TGF beta alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype.

1 reference

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7 January 2021

Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis

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7 January 2021

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

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7 January 2021

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

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7 January 2021

How a growth control path takes a wrong turn to cancer

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7 January 2021

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

1 reference

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7 January 2021

10.1016/S1359-6101(99)00027-1

Identifiers

DOI

1 reference

29 July 2017

1 reference