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The role of SLP-76 and LAT in lymphocyte development
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scholarly article
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Europe PubMed Central
PubMed ID
10712938
retrieved
29 July 2017
review article
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Europe PubMed Central
title
The role of SLP-76 and LAT in lymphocyte development
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10712938
retrieved
29 July 2017
author name string
Pivniouk VI
series ordinal
1
1 reference
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Europe PubMed Central
PubMed ID
10712938
retrieved
29 July 2017
Geha RS
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
10712938
retrieved
29 July 2017
publication date
1 April 2000
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Europe PubMed Central
PubMed ID
10712938
retrieved
29 July 2017
published in
Current Opinion in Immunology
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stated in
Europe PubMed Central
PubMed ID
10712938
retrieved
29 July 2017
volume
12
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Europe PubMed Central
PubMed ID
10712938
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29 July 2017
issue
2
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Europe PubMed Central
PubMed ID
10712938
retrieved
29 July 2017
page(s)
173-178
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Europe PubMed Central
PubMed ID
10712938
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29 July 2017
cites work
Structure and function of the pre-T cell receptor
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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Early T lymphocyte progenitors
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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RAG-1-deficient mice have no mature B and T lymphocytes
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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
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Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells
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The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages
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T cell development in mice lacking the CD3-zeta/eta gene.
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7 January 2021
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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages
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Profound block in thymocyte development in mice lacking p56lck
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T cell antigen receptor signal transduction pathways
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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TcR zeta/CD3 signal transduction in T-cells: downstream signalling via ZAP-70, SLP-76 and FYB.
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
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Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells
1 reference
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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The role of Grb2-associated proteins in T-cell activation
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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BLNK: a central linker protein in B cell activation
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
1 reference
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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Localization of LAT in glycolipid-enriched microdomains is required for T cell activation
1 reference
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
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Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line
1 reference
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway
1 reference
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
1 reference
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
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Lck regulates Vav activation of members of the Rho family of GTPases
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Crossref
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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based on heuristic
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Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
1 reference
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.
1 reference
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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
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A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
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Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential signaling by lymphocyte antigen receptors.
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reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
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A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role of LAT in T cell development
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta tra
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
NK cytokine secretion and cytotoxicity occur independently of the SLP-76 adaptor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Pleiotropic changes controlled by the pre-T-cell receptor
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0952-7915(99)00068-0
1 reference
stated in
Europe PubMed Central
PubMed ID
10712938
retrieved
29 July 2017
PubMed ID
10712938
1 reference
stated in
Europe PubMed Central
PubMed ID
10712938
retrieved
29 July 2017
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