(Q33891522)

English

Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete

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Europe PubMed Central

PubMed publication ID

29 July 2017

Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Claus Schneider

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Rowlinson SW

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Crews BC

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

Goodwin DC

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Gierse JK

5

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Europe PubMed Central

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29 July 2017

Marnett LJ

6

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29 July 2017

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publication date

1 March 2000

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Europe PubMed Central

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29 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

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29 July 2017

275

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Europe PubMed Central

PubMed publication ID

29 July 2017

9

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Europe PubMed Central

PubMed publication ID

29 July 2017

6586-6591

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Prostaglandin endoperoxide synthase: structure and catalysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Inflammation, reproduction, cancer and all that.... The regulation and role of the inducible prostaglandin synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Prostaglandin synthase 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Aspirin-like molecules that covalently inactivate cyclooxygenase-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15-R-HETE synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Isolation and covalent structure of the aspirin-modified, active-site region of prostaglandin synthetase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.9.6586

21 January 2018

Identifiers

10.1074/JBC.275.9.6586

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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