(Q33894829)

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Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

Alzheimer's disease

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2

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Masha Savelieff

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Jeffrey Brender

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Ayyalusamy Ramamoorthy

12

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Sanghyun Lee

1

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13 June 2020

Janarthanan Krishnamoorthy

3

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13 June 2020

Hyun Min Park

5

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13 June 2020

Jin Hoon Kim

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Jeffrey S Derrick

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Akiko Kochi

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Hyuck Jin Lee

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Cheal Kim

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Michael T Bowers

13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Mi Hee Lim

14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

language of work or name

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publication date

27 December 2013

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PubMed publication ID

29 July 2017

Journal of the American Chemical Society

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13 June 2020

136

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13 June 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

299-310

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Untangling amyloid-β, tau, and metals in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Recent studies of antioxidant quinoline derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Reactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Drug repositioning for Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Werner coordination chemistry and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Bioinorganic chemistry of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Metal-associated amyloid-β species in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aβ42 protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Aβ(39-42) modulates Aβ oligomerization but not fibril formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Misfolded proteins in Alzheimer's disease and type II diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

A partially folded structure of amyloid-beta(1-40) in an aqueous environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Myricetin: a naturally occurring regulator of metal-induced amyloid-β aggregation and neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Kinetics of amyloid beta monomer-to-oligomer exchange by NMR relaxation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Small molecule modulators of copper-induced Abeta aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Copper and zinc binding to amyloid-beta: coordination, dynamics, aggregation, reactivity and metal-ion transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Alzheimer's disease, metal ions and metal homeostatic therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Alzheimer's disease: from pathology to therapeutic approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Metals in neurobiology: probing their chemistry and biology with molecular imaging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

The biochemistry and medical significance of the flavonoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Antioxidant activity applying an improved ABTS radical cation decolorization assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Structure-antioxidant activity relationships of flavonoids and phenolic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

5 July 2018

Natural compounds against Alzheimer's disease: molecular recognition of Aβ1-42 peptide by Salvia sclareoides extract and its major component, rosmarinic acid, as investigated by NMR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-β aggregation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Effects of clioquinol on metal-triggered amyloid-beta aggregation revisited

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Association of highly compact type II diabetes related islet amyloid polypeptide intermediate species at physiological temperature revealed by diffusion NMR spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Combating Alzheimer's disease with multifunctional molecules designed for metal passivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Characterization of chemical exchange between soluble and aggregated states of beta-amyloid by solution-state NMR upon variation of salt conditions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Alzheimer's Abeta40 studied by NMR at low pH reveals that sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) binds and promotes beta-ball oligomerization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Chromatin immunoprecipitation: a tool for studying histone acetylation and transcription factor binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

High throughput artificial membrane permeability assay for blood-brain barrier.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Novel stilbenes as probes for amyloid plaques.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

29 October 2018

Very Fast Two-Dimensional NMR Spectroscopy for Real-Time Investigation of Dynamic Events in Proteins on the Time Scale of Seconds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096303

10 December 2018

A Pro-Chelator Triggered by Hydrogen Peroxide Inhibits Iron-Promoted Hydroxyl Radical Formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24397771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2013 Alzheimer's disease facts and figures

1 reference

https://pubmed.ncbi.nlm.nih.gov/24397771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PAMPA--critical factors for better predictions of absorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/24397771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct nitric oxide detection in aqueous solution by copper(II) fluorescein complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24397771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA409801P

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24397771%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

ResearchGate publication ID

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